溃疡性结肠炎的结肠动力。
Colonic motility in ulcerative colitis.
机构信息
Gastroenterology Section, Department of Medicine, University of Perugia, Perugia, Italy.
Gastroenterology Unit, Perugia General Hospital, Perugia, Italy.
出版信息
United European Gastroenterol J. 2014 Dec;2(6):457-62. doi: 10.1177/2050640614548096.
BACKGROUND
Inflammatory conditions affecting the gut may cause motility disturbances, and ulcerative colitis - one of the main disorders among the inflammatory bowel diseases - may display abnormal colonic motility.
AIM
To review the abnormalities of the large bowel in ulcerative colitis, by considering the motility, laboratory (in vitro) and pathological studies dealing with this topic.
METHODS
A comprehensive online search of Medline and the Science Citation Index was carried out.
RESULTS
Patients with ulcerative colitis frequently display colonic motor abnormalities, including lack of contractility, an increase of propulsive contractile waves, an excessive production of nitric oxide, vasoactive intestinal polypeptide nerves, interleukin 1 beta, neurotensin, tachykinins levels and the weaker action of substance P, likely related to a neuromuscular dysfunction due to the inflammatory process.
CONCLUSIONS
A better understanding of the pathophysiological grounds of altered colonic motility in ulcerative colitis may lead to a more in-depth knowledge of the accompanying symptoms and to better and more targeted therapeutic approaches.
背景
影响肠道的炎症状态可能导致运动障碍，而溃疡性结肠炎 - 炎症性肠病的主要疾病之一 - 可能表现出异常的结肠运动。
目的
通过考虑涉及该主题的动力、实验室（体外）和病理学研究，来综述溃疡性结肠炎的大肠异常。
方法
对 Medline 和科学引文索引进行了全面的在线搜索。
结果
溃疡性结肠炎患者经常表现出结肠运动异常，包括缺乏收缩力、推进性收缩波增加、一氧化氮、血管活性肠肽神经、白细胞介素 1β、神经降压素、速激肽水平增加以及 P 物质的作用减弱，这可能与炎症过程导致的神经肌肉功能障碍有关。
结论
更好地了解溃疡性结肠炎中结肠运动改变的病理生理基础，可能会深入了解伴随的症状，并提供更好和更有针对性的治疗方法。
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