He Sijia, Huang Qian, Cheng Jin
Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Oncology, Jiuquan Branch of Shanghai General Hospital, Jiuquan, Gansu, China.
Front Immunol. 2025 Mar 25;16:1531695. doi: 10.3389/fimmu.2025.1531695. eCollection 2025.
Gasdermins (GSDMs) are an important family of proteins that have received extensive attention in tumor research in recent years. They directly induce tumor cell death by mediating pyroptosis and also regulate the recognition and clearance of tumor cells by the immune system by affecting the microenvironment. Therefore, it is of great significance to investigate the role of GSDMs in tumor development and tumor microenvironment. It can not only reveal new mechanisms of cancer development, but also provide theoretical basis for the development of novel anti-tumor therapeutic strategies. This literature review aims to systematically summarize the dual roles of GSDMs in tumor development and their interactions with the tumor microenvironment, and to focus on the importance of GSDM-mediated pyroptosis in anti-cancer therapy, with a view to providing guidance for future research directions.
gasdermin蛋白（GSDMs）是一类重要的蛋白质家族，近年来在肿瘤研究中受到广泛关注。它们通过介导细胞焦亡直接诱导肿瘤细胞死亡，还通过影响微环境来调节免疫系统对肿瘤细胞的识别和清除。因此，研究GSDMs在肿瘤发生发展及肿瘤微环境中的作用具有重要意义。这不仅可以揭示癌症发生发展的新机制，还可为新型抗肿瘤治疗策略的开发提供理论依据。本文献综述旨在系统总结GSDMs在肿瘤发生发展中的双重作用及其与肿瘤微环境的相互作用，并着重探讨GSDM介导的细胞焦亡在抗癌治疗中的重要性，以期为未来的研究方向提供指导。
