Zhou Jianshun, Wang Lifeng, Zhong Zhaoying, Yuan Lei, Huang Jinhua, Zou Ping, Cao Xiaohui, Peng Donglan, Liao Baozhen, Zeng Jianqiang
Department of Anesthesiology, Ganzhou Cancer Hospital, Ganzhou, Jiangxi, China.
Department of Anesthesiology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.
Front Pharmacol. 2025 Mar 25;16:1572112. doi: 10.3389/fphar.2025.1572112. eCollection 2025.
Propofol has become one of the most commonly used anesthetic agents because of its good sedative effects, rapid onset, and fast metabolism. However, its associated respiratory and circulatory depression and injection pain make it difficult for patients to tolerate. Ciprofol, which is structurally similar to propofol but has an additional cyclopropyl group, is less likely to impact respiratory and circulatory function and cause injection pain, highlighting its potential for clinical application. Currently, as research on Ciprofol is still in the exploratory stage, its clinical application is limited because its underlying mechanisms are not yet fully understood. The aim of this article is to review the pharmacological mechanisms of propofol, hypothesize the primary pharmacological effects and potential adverse reactions of Ciprofol, and summarize its current clinical application status, with the goal of providing a reference for future clinical use.
丙泊酚因其良好的镇静效果、起效迅速和代谢快，已成为最常用的麻醉剂之一。然而，其相关的呼吸和循环抑制以及注射痛使患者难以耐受。环泊酚在结构上与丙泊酚相似，但有一个额外的环丙基，不太可能影响呼吸和循环功能，也不易引起注射痛，凸显了其临床应用潜力。目前，由于对环泊酚的研究仍处于探索阶段，其临床应用受到限制，因为其潜在机制尚未完全明确。本文旨在综述丙泊酚的药理机制，推测环泊酚的主要药理作用和潜在不良反应，并总结其目前的临床应用现状，以为未来临床应用提供参考。
