运动训练对心肌梗死后左心室收缩和舒张功能的影响：系统评价与荟萃分析

Effects of exercise training on left ventricular systolic and diastolic function after myocardial infarction: systematic review and meta-analysis.

作者信息

Zhang XiaoMing, Mi Yao, Ding Mingwang, Gao Xin

机构信息

The First Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou, Gansu, China.

Lanzhou University, Lanzhou, Gansu, China.

出版信息

Front Cardiovasc Med. 2025 Mar 25;12:1526326. doi: 10.3389/fcvm.2025.1526326. eCollection 2025.

OBJECTIVES

Exercise training is a rehabilitative approach to improve cardiac function in patients with myocardial infarction. However, evidence on the effectiveness of exercise training in these patients remains limited. In this meta-analysis, we aim to evaluate the extent to which exercise training improves cardiac function in patients with myocardial infarction.

METHODS

We conducted a systematic search of the PubMed, Embase, Cochrane Library, and Web of Science databases to compare cardiac function in myocardial infarction patients who received exercise training combined with standard pharmacological therapy. The cardiac function indicators evaluated included: LVEF, E, E/A, LVIDd, LVIDs, NT-proBNP, E' septal, GLS, and LVMI.

RESULTS

The final analysis included 12 studies with a total of 922 patients. Compared with the standard treatment group, exercise training significantly improved LVEF (MD = 3.99, 95% CI: 1.30-6.68) and (MD = 3.86, 95% CI: 1.33-6.39) in myocardial infarction patients, while showing no significant improvement in the remaining indicators.

SYSTEMATIC REVIEW REGISTRATION

https://www.crd.york.ac.uk/PROSPERO/view/CRD42024571194, PROSPERO (CRD42024571194).

目的

运动训练是改善心肌梗死患者心脏功能的一种康复方法。然而，关于运动训练对这些患者有效性的证据仍然有限。在这项荟萃分析中，我们旨在评估运动训练在多大程度上改善心肌梗死患者的心脏功能。

方法

我们对PubMed、Embase、Cochrane图书馆和Web of Science数据库进行了系统检索，以比较接受运动训练联合标准药物治疗的心肌梗死患者的心脏功能。评估的心脏功能指标包括：左心室射血分数（LVEF）、E峰、E/A比值、左心室舒张末期内径（LVIDd）、左心室收缩末期内径（LVIDs）、N末端B型利钠肽原（NT-proBNP）、室间隔E'峰、整体纵向应变（GLS）和左心室质量指数（LVMI）。