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粪便糖皮质激素代谢物可作为宽吻海豚的应激指标。

Fecal glucocorticoid metabolites can be used as a stress indicator in bottlenose dolphins ().

作者信息

Ferenczi Estelle, Mercera Birgitta, Mercera Karl, Gilbert Caroline, Delfour Fabienne, Pilot-Storck Fanny

机构信息

ADVETIA Centre Hospitalier Vétérinaire, Vélizy-Villacoublay, France.

Parc Astérix, Delphinarium, Plailly, France.

出版信息

Open Vet J. 2025 Feb;15(2):911-922. doi: 10.5455/OVJ.2025.v15.i2.40. Epub 2025 Feb 28.

DOI:10.5455/OVJ.2025.v15.i2.40
PMID:40201809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11974292/
Abstract

BACKGROUND

Glucocorticoids increase in response to the hypothalamic-pituitary-adrenal axis stimulation, and their metabolites can be measured in dolphins' feces.

AIM

This study aimed to assess the welfare of bottlenose dolphins under human care by measuring fecal glucocorticoid metabolites (FGM).

METHODS

Our study consisted of measuring glucocorticoid metabolites concentration by enzyme immunoassay in fecal samples from five bottlenose dolphins housed in a dolphinarium. Dolphins were sampled once a month over a year, and 1 day before and 2 days after the three stressful events.

RESULTS

We confirmed the validation of an extraction technique and an enzyme immunoassay to measure FGM and we observed an increase in their concentration after the stressful events, which provides a biological validation of this method. In parallel, we confirmed that males had a higher concentration of FGM than females, with a basal concentration of around 80 and 50 ng/g of dried feces, respectively.

CONCLUSION

Our study confirms that FGM measurement is a relevant indicator of stress response in bottlenose dolphins under human care, although it needs to take into account the sex and reproductive status of the animals.

摘要

背景

糖皮质激素会因下丘脑 - 垂体 - 肾上腺轴的刺激而增加，其代谢产物可在海豚粪便中检测到。

目的

本研究旨在通过测量粪便糖皮质激素代谢产物（FGM）来评估人工饲养宽吻海豚的福利状况。

方法

我们的研究包括通过酶免疫测定法测量来自海豚馆中五只宽吻海豚粪便样本中糖皮质激素代谢产物的浓度。在一年的时间里，每月对海豚进行一次采样，并且在三次应激事件发生前1天和后2天进行采样。

结果

我们证实了一种提取技术和一种酶免疫测定法用于测量FGM的有效性，并且我们观察到应激事件后其浓度有所增加，这为该方法提供了生物学验证。同时，我们证实雄性海豚的FGM浓度高于雌性，基础浓度分别约为每克干粪便80和50纳克。

结论

我们的研究证实，测量FGM是人工饲养宽吻海豚应激反应的一个相关指标，尽管需要考虑动物的性别和生殖状态。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8c2/11974292/75dadfd24816/OpenVetJ-15-911-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8c2/11974292/3870ca9f0b68/OpenVetJ-15-911-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8c2/11974292/0eed0195f74d/OpenVetJ-15-911-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8c2/11974292/8fbb144a737c/OpenVetJ-15-911-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8c2/11974292/9be5326335c1/OpenVetJ-15-911-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8c2/11974292/df227e718c74/OpenVetJ-15-911-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8c2/11974292/26692d1abf5d/OpenVetJ-15-911-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8c2/11974292/75dadfd24816/OpenVetJ-15-911-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8c2/11974292/3870ca9f0b68/OpenVetJ-15-911-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8c2/11974292/0eed0195f74d/OpenVetJ-15-911-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8c2/11974292/8fbb144a737c/OpenVetJ-15-911-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8c2/11974292/9be5326335c1/OpenVetJ-15-911-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8c2/11974292/df227e718c74/OpenVetJ-15-911-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8c2/11974292/26692d1abf5d/OpenVetJ-15-911-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8c2/11974292/75dadfd24816/OpenVetJ-15-911-g007.jpg

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Influence of season, age, sex, and time of day on the endocrine profile of the common bottlenose dolphin (Tursiops truncatus).
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Gen Comp Endocrinol. 2021 Nov 1;313:113889. doi: 10.1016/j.ygcen.2021.113889. Epub 2021 Aug 20.
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Behavioural Diversity Study in Bottlenose Dolphin () Groups and Its Implications for Welfare Assessments.宽吻海豚群体行为多样性研究及其对福利评估的意义。
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