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肉桂油（）对雄性糖尿病大鼠（）肾脏组织学的影响。

Effect of cinnamon oil () on the histological kidney of male diabetic rats ().

作者信息

Budiastuti Budiastuti, Noviana Thesia Naomi Lan, Plumeriastuti Hani, Effendi Mustofa Helmi, Ugbo Emmanuel Nnabuike, Khairullah Aswin Rafif, Moses Ikechukwu Benjamin, Priscilia Riwu Katty Hendriana, Ahmad Riza Zainuddin, Yanestria Sheila Marty, Wasito Wasito, Pratama Bima Putra, Awwanah Mo, Prasetyo Agung

机构信息

Study Program of Pharmacy Science, Faculty of Health Science, Universitas Muhammadiyah Surabaya, Surabaya, Indonesia.

Master Program of Veterinary Science and Public Health, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia.

出版信息

Open Vet J. 2025 Feb;15(2):923-930. doi: 10.5455/OVJ.2025.v15.i2.41. Epub 2025 Feb 28.

DOI:10.5455/OVJ.2025.v15.i2.41
PMID:40201834
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11974283/
Abstract

BACKGROUND

Chronic systemic disease known as diabetes mellitus is defined by elevated blood glucose levels and problems with fat, carbohydrate, and protein metabolism. In Indonesia, the cinnamon species found include , which also has hypoglycemic activity. The primary antioxidant chemicals found in bark extract are polyphenols, which include tannins and flavonoids.

AIM

The antidiabetic activity of cinnamon essential oil () against streptozotocin (STZ) was examined in this study.

METHODS

STZ (45 mg/kg BW) was administered intraperitoneally as a single dose. Twenty male rats were employed in this investigation. The rats were divided into five groups: treatment 1 (P1) was administered with STZ and provided with 100 mg/kg BW; treatment 2 (P2) was administered with STZ and provided with 200 mg/kg BW; and treatment 3 (P3) was administered with STZ and provided with 400 mg/kg BW. The negative control group (K-) was not treated with STZ and was treated with 1% Tween 80. For 14 days, the medication was administered daily.

RESULTS

The essential oil of cinnamon may lessen glomerulosclerosis, tubular necrosis, tubular degeneration, and glomerular necrosis. The kidney P3 treatment (400 mg/kg BW) produced negligible effects.

CONCLUSION

It is possible to create cinnamon essential oil as an herbal antidiabetic medication by lowering the degree of kidney cell damage.

摘要

背景

糖尿病是一种慢性全身性疾病，其定义为血糖水平升高以及脂肪、碳水化合物和蛋白质代谢出现问题。在印度尼西亚发现的肉桂品种包括 ，其也具有降血糖活性。在 树皮提取物中发现的主要抗氧化化学物质是多酚，其中包括单宁和类黄酮。

目的

本研究检测了肉桂精油（ ）对链脲佐菌素（STZ）的抗糖尿病活性。

方法

以45mg/kg体重的剂量腹腔注射单剂量STZ。本研究使用了20只雄性大鼠。将大鼠分为五组：治疗组1（P1）注射STZ并给予100mg/kg体重的 ；治疗组2（P2）注射STZ并给予200mg/kg体重的 ；治疗组3（P3）注射STZ并给予400mg/kg体重的 。阴性对照组（K-）不注射STZ，给予1%吐温80。每天给药14天。

结果

肉桂精油可减轻肾小球硬化、肾小管坏死、肾小管变性和肾小球坏死。肾脏P3治疗组（400mg/kg体重）产生的影响可忽略不计。

结论

通过降低肾细胞损伤程度，有可能将肉桂精油制成一种草药抗糖尿病药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a6d/11974283/f951c90d5237/OpenVetJ-15-923-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a6d/11974283/afb5eb2a7486/OpenVetJ-15-923-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a6d/11974283/137a07813639/OpenVetJ-15-923-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a6d/11974283/720894c78c42/OpenVetJ-15-923-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a6d/11974283/f951c90d5237/OpenVetJ-15-923-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a6d/11974283/afb5eb2a7486/OpenVetJ-15-923-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a6d/11974283/137a07813639/OpenVetJ-15-923-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a6d/11974283/720894c78c42/OpenVetJ-15-923-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a6d/11974283/f951c90d5237/OpenVetJ-15-923-g004.jpg

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本文引用的文献

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EXCLI J. 2023 Feb 21;22:274-294. doi: 10.17179/excli2022-5720. eCollection 2023.
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Effects of antidiabetic agents on Alzheimer's disease biomarkers in experimentally induced hyperglycemic rat model by streptozocin.在链脲佐菌素诱导的高血糖大鼠模型中，抗糖尿病药物对阿尔茨海默病生物标志物的影响。
PLoS One. 2022 Jul 8;17(7):e0271138. doi: 10.1371/journal.pone.0271138. eCollection 2022.
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Advanced Glycation End Products and Diabetes Mellitus: Mechanisms and Perspectives.
糖基化终产物与糖尿病：机制与展望。
Biomolecules. 2022 Apr 4;12(4):542. doi: 10.3390/biom12040542.
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Molecules. 2022 Jan 27;27(3):853. doi: 10.3390/molecules27030853.
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Glycogen synthesis and beyond, a comprehensive review of GSK3 as a key regulator of metabolic pathways and a therapeutic target for treating metabolic diseases.糖原合成及其他：GSK3 作为代谢途径关键调节剂的综合综述及作为代谢疾病治疗靶点的潜力。
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