Machaca Khaled
Ca2+ signaling Group, Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation, Doha, Qatar; Department of Physiology and Biophysics, Weill Cornell Medicine, NY, USA.
Cell Calcium. 2025 May;127:103016. doi: 10.1016/j.ceca.2025.103016. Epub 2025 Apr 1.
Dendritic Ca signaling is critical for neural transmission and signal processing, however the detailed molecular mechanisms have not been elucidated. Using elegant and complementary imaging approaches Benedetti et al. discover a distinctive ER ladder architecture in dendrites and show that precise localization of Ca signaling proteins at endoplasmic reticulum (ER)-plasma membrane (PM) junctions supports integration of Ca signaling along the dendrite.
树突状钙信号传导对于神经传递和信号处理至关重要，然而其详细的分子机制尚未阐明。通过巧妙且互补的成像方法，贝内代蒂等人发现了树突中独特的内质网梯状结构，并表明钙信号蛋白在内质网（ER）-质膜（PM）交界处的精确定位支持了沿树突的钙信号整合。
