白细胞介素-9和锌指蛋白转录因子18是生发中心记忆形成因子。

IL-9 and ZBTB18 are germinal center memory makers.

作者信息

Stewart Erica L, Burnett Deborah L

机构信息

School of Biomedical Sciences, University of New South Wales, Faculty of Medicine, Sydney, NSW, Australia; Sydney Institute for Infectious Diseases and the Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia.

School of Biomedical Sciences, University of New South Wales, Faculty of Medicine, Sydney, NSW, Australia; Cellular Futures Institute, University of New South Wales, Faculty of Medicine, Sydney, NSW, Australia; Garvan Institute of Medical Research, Sydney, NSW, Australia.

出版信息

Immunity. 2025 Apr 8;58(4):773-775. doi: 10.1016/j.immuni.2025.03.010.

DOI:10.1016/j.immuni.2025.03.010

PMID:40203804

Abstract

Long-lived memory B cells developing from germinal centers (GCs) are important contributors to protective immunity. In this issue of Immunity, Luo et al. report that during primary responses, T cell-derived interleukin-9 potentiates differentiation of GC memory precursors into functional memory B cells in a manner dependent on the transcriptional regulator ZBTB18.

摘要

从生发中心（GCs）发育而来的长寿记忆B细胞是保护性免疫的重要贡献者。在本期《免疫》杂志中，罗等人报道，在初次免疫反应期间，T细胞衍生的白细胞介素-9以依赖转录调节因子ZBTB18的方式增强GC记忆前体向功能性记忆B细胞的分化。