Liao Zhichao, Tan Xinzhe, Liu Yichang, Li Wenqiang, Wang Gengjian, Wang Dongyan
Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.
Heilongjiang University of Chinese Medicine Affiliated Second Hospital, Harbin, Heilongjiang, China
BMJ Open. 2025 Apr 9;15(4):e095309. doi: 10.1136/bmjopen-2024-095309.
OBJECTIVE: Several studies have indicated that transcutaneous electrical nerve stimulation, functional electrical stimulation, neuromuscular electrical stimulation and electroacupuncture exhibit certain therapeutic effects in the treatment of rheumatoid arthritis (RA). However, definitive proof of the effectiveness of different types of electrical stimulation in relieving the different symptomatic manifestations of RA is required. This study aims to analyse the efficacy (health assessment questionnaire, visual analogue scale, etc), safety (adverse reactions) of electrical stimulation for functional impairment (morning stiffness and decreased muscle strength) and pain (joint tenderness and swelling) of RA, and to explore their comparative advantages and potential benefits for patients. METHODS: We will conduct a systematic and comprehensive search of eight databases, and the search will proceed from the beginning to 5 September 2024. Two reviewers will independently screen the retrieved literature to determine the final included studies. Two reviewers will independently assess the risk of bias for all included eligible studies using the Cochrane Risk of Bias tool (V.2.0). Data synthesis will be performed using a random-effects model for network meta-analysis to compare the efficacy and safety of different electrical stimulations. The surface under the cumulative ranking curve will be used to demonstrate the probability of the benefits and harms of interventions. Funnel plots will be used to detect potential publication bias and small sample study effects. The strength of the evidence will be assessed through the Grading of Recommendations, Assessment, Development and Evaluation framework. ETHICS AND DISSEMINATION: Our study data comes from public databases, and the entire study does not directly involve patients and the public, so ethical approval is not required. The final study results will be peer-reviewed and published in a journal. PROSPERO REGISTRATION NUMBER: CRD42024586835.
目的:多项研究表明,经皮电神经刺激、功能性电刺激、神经肌肉电刺激和电针在类风湿关节炎(RA)治疗中显示出一定疗效。然而,需要确凿证据证明不同类型的电刺激在缓解RA不同症状表现方面的有效性。本研究旨在分析电刺激对RA功能障碍(晨僵和肌肉力量下降)和疼痛(关节压痛和肿胀)的疗效(健康评估问卷、视觉模拟量表等)、安全性(不良反应),并探讨其对患者的比较优势和潜在益处。 方法:我们将对八个数据库进行系统全面的检索,检索时间从开始至2024年9月5日。两名评审员将独立筛选检索到的文献以确定最终纳入的研究。两名评审员将使用Cochrane偏倚风险工具(V.2.0)独立评估所有纳入的合格研究的偏倚风险。将使用随机效应模型进行网络荟萃分析来比较不同电刺激的疗效和安全性。累积排序曲线下面积将用于展示干预措施利弊的概率。漏斗图将用于检测潜在的发表偏倚和小样本研究效应。将通过推荐分级、评估、制定和评价框架评估证据的强度。 伦理与传播:我们的研究数据来自公共数据库,整个研究不直接涉及患者和公众,因此无需伦理批准。最终研究结果将经过同行评审并发表在期刊上。 PROSPERO注册号:CRD42024586835。
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