College of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Department of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, Shandong, China.
BMJ Open. 2023 May 2;13(5):e068019. doi: 10.1136/bmjopen-2022-068019.
Depression is the most dominant non-motor symptom of Parkinson's disease (PD), with a prevalence of up to 50%, and can lead to a range of psychiatric and psychological problems that can affect quality of life and overall functioning. While several randomised controlled trials (RCTs) have tested the effect of certain non-pharmacological interventions on the outcome of PD depression symptoms, the comparative benefits and harms of these remain unclear. We will conduct a systematic review and network meta-analysis to compare the efficacy and safety of different non-pharmacological interventions for patients with PD depression.
We will search PubMed, Web of Science, Cochrane, Embase, Google Scholar, the Chinese National Knowledge Infrastructure, the Chinese Biomedical Literature Database, WanFang Data and the Chongqing VIP Database from their inception date to June 2022. The studies will be limited to results published in English or Chinese. The primary outcomes will be the changes in the depressive symptoms, while secondary outcomes will include adverse effects and the quality of life. Two researchers will screen those documents that meet the inclusion criteria, extracting data according to the preset table and evaluating the methodological quality of the included studies using the Cochrane Risk of Bias 2.0 Tool. The STATA and ADDIS statistical software will be used to conduct a systematic review and network meta-analysis. A traditional pairwise meta-analysis and a network meta-analysis will be performed to compare the efficacy and safety of different non-pharmacological interventions, ensuring the robustness of the findings. The Grading of Recommendations Assessment, Development and Evaluation system will be used to assess the overall quality of the body of evidence associated with the main results. The publication bias assessment will be conducted using comparison-adjusted funnel plots.
All the data for this study will be extracted from published RCTs. As a literature-based systematic review, this study does not require ethical approval. The results will be disseminated through peer-reviewed journals and national/international conference presentations.
CRD42022347772.
抑郁症是帕金森病（PD）最主要的非运动症状，其患病率高达 50%，可导致一系列精神和心理问题，影响生活质量和整体功能。虽然已有几项随机对照试验（RCT）测试了某些非药物干预措施对 PD 抑郁症状结果的影响，但这些干预措施的相对益处和危害仍不清楚。我们将进行系统评价和网络荟萃分析，以比较不同非药物干预措施治疗 PD 抑郁患者的疗效和安全性。
我们将检索 PubMed、Web of Science、Cochrane、Embase、Google Scholar、中国国家知识基础设施、中国生物医学文献数据库、万方数据和重庆 VIP 数据库，检索时间从建库至 2022 年 6 月。研究将仅限于以英文或中文发表的结果。主要结局将是抑郁症状的变化，次要结局将包括不良反应和生活质量。两位研究人员将筛选符合纳入标准的文献，根据预设表格提取数据，并使用 Cochrane 偏倚风险 2.0 工具评估纳入研究的方法学质量。将使用 STATA 和 ADDIS 统计软件进行系统评价和网络荟萃分析。将进行传统的两两荟萃分析和网络荟萃分析，以比较不同非药物干预措施的疗效和安全性，确保结果的稳健性。将使用推荐评估、制定与评价系统对与主要结果相关的证据体的总体质量进行评估。将使用比较调整后的漏斗图进行发表偏倚评估。
本研究所有数据均来自已发表的 RCT。作为基于文献的系统评价，本研究不需要伦理批准。研究结果将通过同行评议期刊和国家/国际会议报告发表。
PROSPERO 注册号：CRD42022347772。
