Kauke-Navarro Martin, Klimitz Felix J, Knoedler Samuel, Knoedler Leonard, Diatta Fortunay, Safi Ali-Farid
Department of Surgery, Division of Plastic Surgery, Yale School of Medicine, New Haven, CT, USA.
Department of Surgery, Division of Plastic Surgery, Yale School of Medicine, New Haven, CT, USA; Department of Hand-, Plastic and Reconstructive Surgery, Microsurgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg, Ludwigshafen, Germany.
J Craniomaxillofac Surg. 2025 Aug;53(8):1037-1043. doi: 10.1016/j.jcms.2025.03.015. Epub 2025 Apr 8.
Parry-Romberg syndrome (PRS) is a rare disorder characterized by progressive hemifacial atrophy affecting soft tissue and, in severe cases, bone. Reconstructive surgery is commonly used to manage PRS-related facial deformities. This systematic review assesses the current literature on alloplastic implants for facial reconstruction in PRS. Following PRISMA guidelines, we conducted a systematic review across MEDLINE, Google Scholar, and Cochrane databases, including English-language studies on PRS managed with alloplastic implants. Eleven studies, including 74 PRS patients (age range 12-45, mean 22.3), were analyzed. Most patients received off-the-shelf implants, with a single case using a 3D-modeled titanium implant. Implants, often adjunctive to free flap-based soft tissue augmentation, fat grafting, or orthognathic surgery, were typically placed in the malar, mandibular, or mental regions, with porous polyethylene (Medpor) being the most frequently used material. Complications were minimal, with infections (n = 2) and one aesthetic issue requiring removal (follow-up range: six months to 13 years; mean 39 months). Alloplastic implants effectively restore facial symmetry in PRS, commonly alongside soft tissue reconstruction. Future studies on custom-designed implants are warranted to enhance treatment consistency and long-term outcomes.
帕里-罗姆伯格综合征（PRS）是一种罕见的疾病，其特征为进行性半侧面部萎缩，累及软组织，严重时累及骨骼。重建手术常用于治疗与PRS相关的面部畸形。本系统评价评估了目前关于用于PRS面部重建的异体植入物的文献。按照PRISMA指南，我们对MEDLINE、谷歌学术和考克兰数据库进行了系统评价，纳入了关于使用异体植入物治疗PRS的英文研究。分析了11项研究，包括74例PRS患者（年龄范围12 - 45岁，平均22.3岁）。大多数患者接受现成的植入物，仅有1例使用3D建模钛植入物。植入物通常作为基于游离皮瓣的软组织增大、脂肪移植或正颌手术的辅助手段，通常置于颧骨、下颌或颏部区域，多孔聚乙烯（Medpor）是最常用的材料。并发症极少，有2例感染，1例因美学问题需要取出（随访时间范围：6个月至13年；平均39个月）。异体植入物可有效恢复PRS患者的面部对称性，通常与软组织重建同时进行。有必要对定制植入物开展进一步研究，以提高治疗的一致性和长期效果。
