Mi Liangyu, He Xiaoyao, Gao Jinfang, Xu Ke
Shanxi Bethune Hospital, Third Hospital of Shanxi Medical University, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, China.
Department of Statistics, School of Public Health, Shanxi Medical University, Taiyuan, 030032, China.
Sci Rep. 2025 Apr 9;15(1):12188. doi: 10.1038/s41598-025-97373-w.
Gout, a common inflammatory arthritis, is associated with elevated monocyte levels and reduced high-density lipoprotein cholesterol (HDL-C). However, the relationship between the monocyte-to-HDL-C ratio (MHR) and gout risk remains unexplored. This study investigates the association between MHR and gout risk, examines the role of MHR in gout with comorbid renal dysfunction, and provides a theoretical basis for gout prevention and treatment. Using data from the National Health and Nutrition Examination Survey (NHANES, 2005-2016), a cross-sectional analysis was conducted to assess the correlation between MHR levels and gout. Multiple logistic regression, subgroup analyses, and exploration of nonlinear relationships were employed. Among 7247 participants, MHR was significantly higher in gout patients (0.54 ± 0.31) compared to non-gout patients (0.47 ± 0.24). After adjustments, MHR was significantly associated with gout risk (OR = 1.6, 95%CI 1.1-2.2, P = 0.012). Subgroup analyses revealed a positive correlation between MHR and gout risk in males, Mexican Americans, married individuals, those with insufficient physical activity, and diabetic patients. In gout patients with renal dysfunction, MHR was 0.6 ± 0.5, showing a stronger positive association (OR = 7.4, 95%CI 2.2-25.3, P = 0.001). The prevalence of gout with renal dysfunction in the highest MHR quartile was 1.7 times higher than in the lowest quartile (OR = 2.7, 95%CI 1.1-6.7, P = 0.028). These findings suggest a significant positive correlation between MHR and gout risk in U.S. adults, as well as a link between MHR and the severity of renal dysfunction in gout patients. MHR may serve as a valuable indicator for assessing gout risk and its complications, highlighting the need for further large-scale prospective studies to confirm these results.
痛风是一种常见的炎性关节炎，与单核细胞水平升高及高密度脂蛋白胆固醇（HDL-C）降低有关。然而，单核细胞与HDL-C比值（MHR）和痛风风险之间的关系仍未得到探索。本研究调查MHR与痛风风险之间的关联，探讨MHR在合并肾功能不全的痛风中的作用，并为痛风的预防和治疗提供理论依据。利用美国国家健康与营养检查调查（NHANES，2005 - 2016年）的数据，进行横断面分析以评估MHR水平与痛风之间的相关性。采用了多重逻辑回归、亚组分析以及非线性关系探索。在7247名参与者中，痛风患者的MHR（0.54±0.31）显著高于非痛风患者（0.47±0.24）。经过调整后，MHR与痛风风险显著相关（OR = 1.6，95%CI 1.1 - 2.2，P = 0.012）。亚组分析显示，在男性、墨西哥裔美国人、已婚者、体力活动不足者及糖尿病患者中，MHR与痛风风险呈正相关。在合并肾功能不全的痛风患者中，MHR为0.6±0.5，显示出更强的正相关（OR = 7.4，95%CI 2.2 - 25.3，P = 0.001）。MHR最高四分位数组中合并肾功能不全的痛风患病率比最低四分位数组高1.7倍（OR = 2.7，95%CI 1.1 - 6.7，P = 0.028）。这些发现表明，美国成年人中MHR与痛风风险之间存在显著正相关，且MHR与痛风患者肾功能不全的严重程度之间存在关联。MHR可能是评估痛风风险及其并发症的一个有价值指标，这突出表明需要进一步开展大规模前瞻性研究来证实这些结果。
