Zhong Ling, Hou Xiaojie, Tian Yan, Fu Xianghui
Department of Endocrinology and Metabolism, Department of Biotherapy, Laboratory of Diabetes and Metabolism Research, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Department of Cardiovascular Surgery, Cardiovascular Surgery Research Laboratory, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Cardiovasc Diabetol. 2025 Apr 9;24(1):159. doi: 10.1186/s12933-025-02702-y.
The global prevalence of diabetes is rapidly increasing, significantly raising the risk of various cardiovascular diseases. Among these, diabetic cardiomyopathy (DCM) is a distinct and critical complication characterized by ventricular hypertrophy and impaired myocardial contractility, ultimately progressing to heart failure and making it a leading cause of mortality among diabetic patients. Despite advances in pharmacological therapies, the effectiveness of managing cardiac dysfunction in DCM remains challenging. Consequently, exploring additional therapeutic strategies for the prevention and treatment of DCM is urgently needed. Beyond pharmacological approaches, lifestyle modifications, particularly exercise and dietary interventions, play a fundamental role in managing DCM due to their significant cardiovascular benefits in diabetic patients. This review synthesizes recent advancements in the field, elucidating the underlying mechanisms through which exercise and dietary interventions influence DCM pathophysiology. By integrating these strategies, we aim to facilitate the development of personalized exercise and dietary regimens that effectively mitigate or prevent DCM progression.
全球糖尿病患病率正在迅速上升,显著增加了各种心血管疾病的风险。其中,糖尿病性心肌病(DCM)是一种独特且严重的并发症,其特征为心室肥厚和心肌收缩力受损,最终发展为心力衰竭,成为糖尿病患者死亡的主要原因。尽管药物治疗取得了进展,但在DCM中管理心脏功能障碍的有效性仍然具有挑战性。因此,迫切需要探索预防和治疗DCM的其他治疗策略。除了药物治疗方法外,生活方式的改变,特别是运动和饮食干预,由于其对糖尿病患者具有显著的心血管益处,在管理DCM中起着重要作用。本综述综合了该领域的最新进展,阐明了运动和饮食干预影响DCM病理生理学的潜在机制。通过整合这些策略,我们旨在促进制定个性化的运动和饮食方案,有效减轻或预防DCM的进展。
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