Department of Endocrinology and Metabolism, Department of Biotherapy, Center for Diabetes and Metabolism Research, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, Sichuan, China.
Department of General Surgery and Gastric Cancer Center and Laboratory of Gastric Cancer, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Cardiovasc Diabetol. 2024 Sep 16;23(1):344. doi: 10.1186/s12933-024-02405-w.
Diabetic macroangiopathy is a leading cause of diabetes-related mortality worldwide. Both genetic and environmental factors, through a multitude of underlying molecular mechanisms, contribute to the pathogenesis of diabetic macroangiopathy. MicroRNAs (miRNAs), a class of non-coding RNAs known for their functional diversity and expression specificity, are increasingly recognized for their roles in the initiation and progression of diabetes and diabetic macroangiopathy. In this review, we will describe the biogenesis of miRNAs, and summarize their functions in diabetic macroangiopathy, including atherosclerosis, peripheral artery disease, coronary artery disease, and cerebrovascular disease, which are anticipated to provide new insights into future perspectives of miRNAs in basic, translational and clinical research, ultimately advancing the diagnosis, prevention, and treatment of diabetic macroangiopathy.
糖尿病大血管病变是全球范围内导致糖尿病相关死亡的主要原因。遗传和环境因素通过多种潜在的分子机制共同导致糖尿病大血管病变的发病机制。MicroRNAs（miRNAs）是一类非编码 RNA，以其功能多样性和表达特异性而闻名，它们在糖尿病和糖尿病大血管病变的发生和进展中的作用越来越受到重视。在这篇综述中，我们将描述 miRNAs 的生物发生，并总结它们在糖尿病大血管病变中的功能，包括动脉粥样硬化、外周动脉疾病、冠状动脉疾病和脑血管疾病，这有望为 miRNAs 在基础、转化和临床研究中的未来前景提供新的见解，最终促进糖尿病大血管病变的诊断、预防和治疗。
