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Thick or Thin, Durable or Biodegradable Polymers: Does Stent Design Still Matter?

作者信息

Lee Seung-Jun

机构信息

Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.

出版信息

Korean Circ J. 2025 May;55(5):408-409. doi: 10.4070/kcj.2025.0038. Epub 2025 Mar 4.

DOI:10.4070/kcj.2025.0038
PMID:40206003
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12088995/
Abstract
摘要

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Thick or Thin, Durable or Biodegradable Polymers: Does Stent Design Still Matter?厚聚合物还是薄聚合物,耐用聚合物还是可生物降解聚合物:支架设计仍然重要吗?
Korean Circ J. 2025 May;55(5):408-409. doi: 10.4070/kcj.2025.0038. Epub 2025 Mar 4.
2
Biodegradable polymer sirolimus-eluting stents versus durable polymer everolimus-eluting stents in patients with ST-segment elevation myocardial infarction (BIOSTEMI): a single-blind, prospective, randomised superiority trial.生物可降解聚合物西罗莫司洗脱支架与耐久性聚合物依维莫司洗脱支架在 ST 段抬高型心肌梗死患者中的比较(BIOSTEMI):一项单盲、前瞻性、随机优效性试验。
Lancet. 2019 Oct 5;394(10205):1243-1253. doi: 10.1016/S0140-6736(19)31877-X. Epub 2019 Sep 2.
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Ultrathin strut biodegradable polymer sirolimus-eluting stent versus durable polymer everolimus-eluting stent for percutaneous coronary revascularisation (BIOSCIENCE): a randomised, single-blind, non-inferiority trial.超薄支架可生物降解聚合物西罗莫司洗脱支架与耐用聚合物依维莫司洗脱支架经皮冠状动脉血运重建(BIOSCIENCE):一项随机、单盲、非劣效性试验。
Lancet. 2014 Dec 13;384(9960):2111-22. doi: 10.1016/S0140-6736(14)61038-2. Epub 2014 Sep 1.
4
Very thin strut biodegradable polymer everolimus-eluting and sirolimus-eluting stents versus durable polymer zotarolimus-eluting stents in allcomers with coronary artery disease (BIO-RESORT): a three-arm, randomised, non-inferiority trial.非常薄的支撑物可生物降解聚合物依维莫司洗脱和西罗莫司洗脱支架与全人群冠心病使用耐用聚合物佐他莫司洗脱支架(BIO-RESORT):一项三臂、随机、非劣效试验。
Lancet. 2016 Nov 26;388(10060):2607-2617. doi: 10.1016/S0140-6736(16)31920-1. Epub 2016 Oct 30.
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Biodegradable Polymer Biolimus-Eluting Stents Versus Durable Polymer Everolimus-Eluting Stents in Patients With Coronary Artery Disease: Final 5-Year Report From the COMPARE II Trial (Abluminal Biodegradable Polymer Biolimus-Eluting Stent Versus Durable Polymer Everolimus-Eluting Stent).生物可降解聚合物比伐卢定洗脱支架与耐久性聚合物依维莫司洗脱支架治疗冠状动脉疾病患者的比较:来自 COMPARE II 试验的最终 5 年报告(管腔生物可降解聚合物比伐卢定洗脱支架与耐久性聚合物依维莫司洗脱支架)。
JACC Cardiovasc Interv. 2017 Jun 26;10(12):1215-1221. doi: 10.1016/j.jcin.2017.02.029. Epub 2017 May 31.
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Thin, Very Thin, or Ultrathin Strut Biodegradable or Durable Polymer-Coated Drug-Eluting Stents: 3-Year Outcomes of BIO-RESORT.薄、极薄或超薄支架,生物可降解或耐用聚合物涂层药物洗脱支架:BIO-RESORT 的 3 年结果。
JACC Cardiovasc Interv. 2019 Sep 9;12(17):1650-1660. doi: 10.1016/j.jcin.2019.04.054. Epub 2019 Aug 14.
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Abluminal biodegradable polymer biolimus-eluting stent versus durable polymer everolimus-eluting stent (COMPARE II): a randomised, controlled, non-inferiority trial.无聚合物可降解聚合物雷帕霉素洗脱支架与持久性聚合物依维莫司洗脱支架(COMPARE II):一项随机、对照、非劣效性试验。
Lancet. 2013 Feb 23;381(9867):651-60. doi: 10.1016/S0140-6736(12)61852-2. Epub 2013 Jan 30.
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Bare metal stents, durable polymer drug eluting stents, and biodegradable polymer drug eluting stents for coronary artery disease: mixed treatment comparison meta-analysis.冠状动脉疾病用裸金属支架、耐用聚合物药物洗脱支架和可生物降解聚合物药物洗脱支架:混合治疗比较荟萃分析。
BMJ. 2013 Nov 8;347:f6625. doi: 10.1136/bmj.f6625.
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Improved safety and reduction in stent thrombosis associated with biodegradable polymer-based biolimus-eluting stents versus durable polymer-based sirolimus-eluting stents in patients with coronary artery disease: final 5-year report of the LEADERS (Limus Eluted From A Durable Versus ERodable Stent Coating) randomized, noninferiority trial.与含有不可降解聚合物的西罗莫司洗脱支架相比,含可生物降解聚合物的比伐卢定洗脱支架在冠状动脉疾病患者中具有更好的安全性和降低支架血栓形成的风险:LEADERS(雷帕霉素从不可降解到可降解涂层支架洗脱)随机、非劣效性试验的最终 5 年报告。
JACC Cardiovasc Interv. 2013 Aug;6(8):777-89. doi: 10.1016/j.jcin.2013.04.011.
10
Zotarolimus-eluting durable-polymer-coated stent versus a biolimus-eluting biodegradable-polymer-coated stent in unselected patients undergoing percutaneous coronary intervention (SORT OUT VI): a randomised non-inferiority trial.载唑来膦酸雷帕霉素洗脱持久聚合物涂层支架与生物可吸收聚合物涂层雷帕霉素洗脱支架在经皮冠状动脉介入治疗未选择患者中的比较(SORT OUT VI):一项随机非劣效性试验。
Lancet. 2015 Apr 18;385(9977):1527-35. doi: 10.1016/S0140-6736(14)61794-3. Epub 2015 Jan 16.

本文引用的文献

1
Comparison of Thick Biolimus A9-Eluting Stent and Thin Zotarolimus-Eluting Stent in Multi-Vessel Percutaneous Coronary Intervention.多支血管经皮冠状动脉介入治疗中厚壁生物雷帕霉素A9洗脱支架与薄壁佐他莫司洗脱支架的比较。
Korean Circ J. 2025 May;55(5):396-407. doi: 10.4070/kcj.2024.0101. Epub 2025 Feb 17.
2
Durable Polymer Versus Biodegradable Polymer Drug-Eluting Stents After Percutaneous Coronary Intervention in Patients with Acute Coronary Syndrome: The HOST-REDUCE-POLYTECH-ACS Trial.急性冠状动脉综合征患者经皮冠状动脉介入治疗后,耐用聚合物与可生物降解聚合物药物洗脱支架的比较:HOST-REDUCE-POLYTECH-ACS试验
Circulation. 2021 Mar 16;143(11):1081-1091. doi: 10.1161/CIRCULATIONAHA.120.051700. Epub 2020 Nov 18.
3
Newer-Generation Ultrathin Strut Drug-Eluting Stents Versus Older Second-Generation Thicker Strut Drug-Eluting Stents for Coronary Artery Disease.新一代超小径药物洗脱支架与上一代较厚支架药物洗脱支架治疗冠状动脉疾病的比较。
Circulation. 2018 Nov 13;138(20):2216-2226. doi: 10.1161/CIRCULATIONAHA.118.034456.
4
Coronary balloon angioplasty, stents, and scaffolds.冠状动脉球囊血管成形术、支架和支架。
Lancet. 2017 Aug 19;390(10096):781-792. doi: 10.1016/S0140-6736(17)31927-X.
5
Meta-Analysis of Randomized Clinical Trials Comparing Biodegradable Polymer Drug-Eluting Stent to Second-Generation Durable Polymer Drug-Eluting Stents.随机临床试验的荟萃分析比较可生物降解聚合物药物洗脱支架与第二代耐用聚合物药物洗脱支架。
JACC Cardiovasc Interv. 2017 Mar 13;10(5):462-473. doi: 10.1016/j.jcin.2016.12.002.
6
Long-Term Safety of Drug-Eluting and Bare-Metal Stents: Evidence From a Comprehensive Network Meta-Analysis.药物洗脱支架和裸金属支架的长期安全性:来自综合网络荟萃分析的证据。
J Am Coll Cardiol. 2015 Jun 16;65(23):2496-507. doi: 10.1016/j.jacc.2015.04.017.
7
Neoatherosclerosis: overview of histopathologic findings and implications for intravascular imaging assessment.血管新生动脉硬化:组织病理学发现概述及其对血管内影像学评估的影响。
Eur Heart J. 2015 Aug 21;36(32):2147-59. doi: 10.1093/eurheartj/ehv205. Epub 2015 May 20.