Cai Hong, Xing Xue, Su Ying, Yang Chunhui
Department of Clinical Laboratory, The Second Hospital of Dalian Medical University, Dalian, Liaoning, China.
Front Pharmacol. 2025 Mar 26;16:1529468. doi: 10.3389/fphar.2025.1529468. eCollection 2025.
Chromatography coupled with mass spectrometry (MS) has emerged as a cornerstone analytical technique in drug research. Over the years, advancements in chromatography-MS have significantly enhanced its capabilities, leading to improved sensitivity, specificity, and throughput. This review explores the innovative applications of chromatography-MS in drug research, particularly focusing on its role in drug absorption, distribution, metabolism, excretion (ADME), toxicity evaluation, and personalized medicine. It also addresses the future perspectives of this powerful technique, including challenges and potential solutions, and highlights how emerging trends such as high spatial resolution imaging and multimodal integration could revolutionize drug discovery and development. Through these innovations, chromatography-MS promises to contribute substantially to the development of more effective, safer, and personalized therapeutic interventions.
色谱联用质谱（MS）已成为药物研究中的一项基础分析技术。多年来，色谱 - 质谱联用技术的进步显著提升了其性能，从而提高了灵敏度、特异性和通量。本综述探讨了色谱 - 质谱联用技术在药物研究中的创新应用，尤其关注其在药物吸收、分布、代谢、排泄（ADME）、毒性评估和个性化医疗中的作用。它还讨论了这项强大技术的未来前景，包括挑战和潜在解决方案，并强调了高空间分辨率成像和多模态整合等新兴趋势如何能够彻底改变药物发现和开发。通过这些创新，色谱 - 质谱联用技术有望为开发更有效、更安全和个性化的治疗干预措施做出重大贡献。
