Mao Weixu, Liu Xuanjun, Fan Senji, Zhang Ruibin, Liu Miao, Xiao Shunqiong
Department of Respiratory Medicine, The Affiliated Yongchuan Traditional Chinese Medicine Hospital of Chongqing Medical University, Chongqing, China.
Department of General Surgery, The Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing, China.
Front Med (Lausanne). 2025 Mar 26;12:1549658. doi: 10.3389/fmed.2025.1549658. eCollection 2025.
Community-acquired pneumonia (CAP) remains one of the leading respiratory diseases worldwide. With the aging of the global population, the morbidity, criticality and mortality rates of CAP in older adults remain high every year. Modulating the signaling pathways that cause the inflammatory response and improve the immune function of patients has become the focus of reducing inflammatory damage in the lungs, especially CAP in older adults. As an important factor that causes the inflammatory response of CAP and affects the immune status of the body, oxidative stress plays an important role in the occurrence, development and treatment of CAP. Furthermore, in older adults with CAP, oxidative stress is closely associated with immune senescence, sarcopenia, frailty, aging, multimorbidity, and polypharmacy. Therefore, multiple perspectives combined with the disease characteristics of older adults with CAP were reviewed to clarify the research progress and application value of modulating oxidative stress in older adults with CAP. Clearly, there is no doubt that targeted modulation of oxidative stress benefits CAP in older adults. However, many challenges and unknowns concerning how to modulate oxidative stress for further practical clinical applications exist, and more targeted research is needed. Moreover, the limitations and challenges of modulating oxidative stress are analyzed with the aim of providing references and ideas for future clinical treatment or further research in older adults with CAP.
社区获得性肺炎（CAP）仍然是全球主要的呼吸道疾病之一。随着全球人口老龄化，老年人CAP的发病率、重症率和死亡率每年居高不下。调节引起炎症反应的信号通路并改善患者的免疫功能已成为减轻肺部炎症损伤的焦点，尤其是老年人的CAP。氧化应激作为引起CAP炎症反应并影响机体免疫状态的重要因素，在CAP的发生、发展及治疗中发挥重要作用。此外，在老年CAP患者中，氧化应激与免疫衰老、肌肉减少症、衰弱、衰老、多种疾病并存及多重用药密切相关。因此，结合老年CAP患者的疾病特点，从多个角度进行综述，以阐明调节氧化应激在老年CAP患者中的研究进展及应用价值。显然，有针对性地调节氧化应激对老年CAP患者有益。然而，在如何调节氧化应激以进一步应用于临床实践方面，仍存在许多挑战和未知因素，需要更多针对性的研究。此外，分析调节氧化应激的局限性和挑战，旨在为老年CAP患者未来的临床治疗或进一步研究提供参考和思路。
