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PD-L1抑制剂索卡利单抗治疗复发转移性宫颈癌的疗效:一例报告

Promising outcomes of the PD-L1 inhibitor Socazolimab in recurrent and metastatic cervical cancer: a case report.

作者信息

Xu Zichao, Wang Minjie, Gong Long, Luo Guanghong, Zhang Yucong, Zhou Yayan, Li Zihuang

机构信息

The Second Clinical Medical College of Jinan University, Department of Radiotherapy, Shenzhen People's Hospital, Shenzhen, Guangdong, China.

出版信息

Front Oncol. 2025 Mar 24;15:1541760. doi: 10.3389/fonc.2025.1541760. eCollection 2025.

Abstract

Recurrent and metastatic advanced cervical cancer carries a poor prognosis, and there is currently no standardized treatment regimen. Immunotherapy, as an emerging and effective treatment strategy, has attracted significant attention. Socazolimab, a programmed death ligand 1 monoclonal antibody developed in China, is primarily used to treat patients with recurrent or metastatic cervical cancer who have failed or are intolerant to first-line platinum-based chemotherapy, regardless of programmed death ligand 1 expression status. We report the case of a Chinese patient with advanced cervical cancer and multiple metastases, who showed significant tumor regression after receiving Socazolimab treatment. Currently, during ongoing immunotherapy, the tumor continues to demonstrate persistent remission, with no new lesions observed. This case suggests that Socazolimab may offer a promising therapeutic option for patients with metastatic cervical cancer. In this report, the safety profile of Socazolimab was favorable, with no severe or uncontrollable adverse events. This case provides compelling evidence of the antitumor activity and manageable toxicity of Socazolimab in metastatic cervical cancer patients, offering valuable insights for further research and clinical application of the drug.

摘要

复发性和转移性晚期宫颈癌预后较差,目前尚无标准化治疗方案。免疫疗法作为一种新兴的有效治疗策略,已引起广泛关注。索卡利单抗是我国研发的一种程序性死亡配体1单克隆抗体,主要用于治疗一线铂类化疗失败或不耐受的复发性或转移性宫颈癌患者,无论其程序性死亡配体1表达状态如何。我们报告了1例中国晚期宫颈癌伴多发转移患者,接受索卡利单抗治疗后肿瘤显著消退。目前,在正在进行的免疫治疗期间,肿瘤持续缓解,未观察到新病灶。该病例表明,索卡利单抗可能为转移性宫颈癌患者提供一种有前景的治疗选择。在本报告中,索卡利单抗的安全性良好,未出现严重或无法控制的不良事件。该病例为索卡利单抗在转移性宫颈癌患者中的抗肿瘤活性和可管理毒性提供了有力证据,为该药物的进一步研究和临床应用提供了有价值的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5855/11979981/eed74106414e/fonc-15-1541760-g001.jpg

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