Pullen R G
J Physiol. 1985 May;362:273-83. doi: 10.1113/jphysiol.1985.sp015676.
Ventriculo-cisternal perfusion in rabbits has been employed to examine steady-state relations between ventricular sodium and water fluxes and ventricular osmolality. These fluxes have been determined in individual rabbits when the ventricular fluid was either similar to normal cerebrospinal fluid (c.s.f.) or when its osmolality was changed to one value within the range of about 150-300 mosmol/l. The ventricular osmolality was changed by perfusing the ventricles with sucrose solutions of different concentrations that were either ion free, contained a low concentration of sodium, or contained both sodium and furosemide to inhibit the active production of c.s.f. Results suggest that this experimental range of ventricular osmolality is without significant effect upon a constant active sodium-coupled water movement into the ventricles, whereas a passive osmotic water flux into the ventricles increases with ventricular osmolality.
已采用兔脑室-脑池灌注法来研究心室钠和水通量与心室渗透压之间的稳态关系。当心室液类似于正常脑脊液（c.s.f.）或其渗透压改变至约150 - 300毫摩尔/升范围内的某一值时，已在个体兔中测定了这些通量。通过用不同浓度的蔗糖溶液灌注心室来改变心室渗透压，这些蔗糖溶液要么不含离子，要么含有低浓度的钠，要么同时含有钠和呋塞米以抑制脑脊液的主动生成。结果表明，该实验范围内的心室渗透压对持续的钠耦联水主动移入心室没有显著影响，而水被动渗透入心室的通量随心室渗透压增加。
