寒冷暴露对幼鼠降钙素分泌的影响。
Effects of cold exposure on calcitonin secretion in the young rat.
作者信息
Besnard P, Mory G, Barlet J P, Garel J M
出版信息
J Physiol (Paris). 1985;80(1):38-41.
The effects of cold exposure on calcitonin (CT) secretion were evaluated in young rats. Acute cold exposure (5 h to 5 degrees C) induced a rise in plasma CT concentrations and a decrease in thyroidal CT stores without change in total and ionized plasma calcium levels. The cold activation of sympathico-adrenomedullary axis and the inhibition of CT response to cold after beta-antagonist treatment might suggest that endogenous catecholamines can enhance CT secretion in young rats. Cold adaptation (3 weeks to 5 degrees C) induced a fall in plasma calcium concentration and a rise in thyroidal CT stores without change in plasma CT levels. The high plasma glucocorticoid levels which are known to occur during chronic cold exposure could be involved in the rise of thyroidal CT content in cold adapted rats.
在幼鼠中评估了冷暴露对降钙素（CT）分泌的影响。急性冷暴露（5小时至5摄氏度）导致血浆CT浓度升高，甲状腺CT储备减少，而血浆总钙和离子钙水平无变化。交感 - 肾上腺髓质轴的冷激活以及β-拮抗剂治疗后对冷的CT反应抑制可能表明内源性儿茶酚胺可增强幼鼠的CT分泌。冷适应（3周至5摄氏度）导致血浆钙浓度下降，甲状腺CT储备增加，而血浆CT水平无变化。已知在慢性冷暴露期间出现的高血浆糖皮质激素水平可能与冷适应大鼠甲状腺CT含量的增加有关。
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