Wang Mingyue, Gao Xinghua, Zhang Li
Department of Dermatology, The First Hospital of China Medical University, Shenyang, China.
Key Laboratory of Immunodermatology, Ministry of Education and NHC; National Joint Engineering Research Center for Theranostics of Immunological Skin Diseases, Shenyang, China.
Front Microbiol. 2025 Mar 26;16:1564675. doi: 10.3389/fmicb.2025.1564675. eCollection 2025.
Balanoposthitis is a common heterogeneous skin condition involving the glans penis and prepuce, and is seen from infancy to old age. Its predisposing factors are intertrigo, lengthy foreskin, localized irritation, and mucosal injury. The itching and skin inflammation at the glans penis seriously affects the quality of life of patients. As a result of advances in high-throughput sequencing technology, the prepuce microbial colonization patterns and glans penis are now known better. Previous studies have shown that an imbalance of flora can cause balanoposthitis. This article summarizes the progress of research on balanoposthitis and skin microecology, and provides a direction for the subsequent exploration of immunological mechanisms in balanoposthitis.
阴茎头炎是一种常见的异质性皮肤病，累及阴茎头和包皮，可见于从婴儿期到老年期的各个年龄段。其诱发因素包括擦烂红斑、过长的包皮、局部刺激和黏膜损伤。阴茎头处的瘙痒和皮肤炎症严重影响患者的生活质量。由于高通量测序技术的进步，目前对包皮微生物定植模式和阴茎头有了更深入的了解。先前的研究表明，菌群失衡可导致阴茎头炎。本文总结了阴茎头炎与皮肤微生态学的研究进展，为后续阴茎头炎免疫机制的探索提供了方向。
