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严重急性呼吸综合征冠状病毒2型所致展神经麻痹:1例报告及对甲泼尼龙的反应

SARS-CoV-2 induced abducens nerve palsy: A case report and response to methylprednisolone.

作者信息

Santos João Hugo Abdalla, Abdalla Ligia Fernandes, de Souza Sierpinski Cleitiene, Porto Camila Feldberg, Naveca Felipe Gomes

机构信息

Hospital Adventista de Manaus, Brazil.

Universidade Federal do Amazonas, Brazil.

出版信息

IDCases. 2025 Mar 21;40:e02201. doi: 10.1016/j.idcr.2025.e02201. eCollection 2025.

DOI:10.1016/j.idcr.2025.e02201
PMID:40207264
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11979977/
Abstract

INTRODUCTION

The abducens nerve (sixth cranial nerve) is a motor nerve that innervates the lateral rectus muscle, playing a key role in ocular abduction. Palsy of this nerve leads to convergent strabismus and diplopia. Common causes include strokes, trauma, inflammation, and infections, though in some cases, the etiology remains undetermined. With the emergence of COVID-19, neurological manifestations such as cranial neuropathies, including abducens nerve palsy, have been reported.

CASE PRESENTATION

We present a case of a previously healthy 48-year-old male diagnosed with SARS-CoV-2 infection who developed abducens nerve palsy in the left eye. Following the resolution of respiratory symptoms, strabismus persisted. Treatment with methylprednisolone was initiated, resulting in partial recovery within one week and complete resolution after three months.

CONCLUSION

SARS-CoV-2-induced abducens nerve palsy can be reversible with conservative treatment using methylprednisolone. Early recognition and appropriate management are crucial for achieving a favorable prognosis.

摘要

引言

展神经(第六对脑神经)是一条运动神经,支配外直肌,在眼球外展中起关键作用。该神经麻痹会导致内斜视和复视。常见病因包括中风、创伤、炎症和感染,不过在某些情况下,病因仍未明确。随着新冠病毒病(COVID-19)的出现,已报告出现包括展神经麻痹在内的颅神经病变等神经学表现。

病例介绍

我们报告一例先前健康的48岁男性病例,该患者被诊断为感染严重急性呼吸综合征冠状病毒2(SARS-CoV-2),并出现左眼展神经麻痹。呼吸道症状缓解后,斜视持续存在。开始使用甲泼尼龙治疗,一周内部分恢复,三个月后完全恢复。

结论

使用甲泼尼龙进行保守治疗,SARS-CoV-2引起的展神经麻痹可能是可逆的。早期识别和适当管理对于获得良好预后至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc86/11979977/80f68c9ec51a/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc86/11979977/bbe94ee46b3b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc86/11979977/defa00880a1e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc86/11979977/b8dd4f31a183/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc86/11979977/2930e11c5343/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc86/11979977/80f68c9ec51a/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc86/11979977/bbe94ee46b3b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc86/11979977/defa00880a1e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc86/11979977/b8dd4f31a183/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc86/11979977/2930e11c5343/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc86/11979977/80f68c9ec51a/gr5.jpg

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