Liu Jiasu, Yu Xuebin, Chudhary Maryam, Qi Hui, Zhang Na, Zhong Shiwen, Zhao Qi, Ren Xiang, Kong Hui, Kong Li
Department of Histology and Embryology, College of Basic Medicine, Dalian Medical University, Dalian, LiaoNing Provence, China.
Department of Ophthalmology, The Second Hospital of Dalian Medical University, Dalian, LiaoNing Provence, China.
Curr Eye Res. 2025 Jul;50(7):736-744. doi: 10.1080/02713683.2025.2487069. Epub 2025 Apr 10.
To investigate the relationship between Thioredoxin (Trx), Thioredoxin interacting protein (Txnip), and the severity of diabetic retinopathy (DR).
The study involved a total of 101 eyes, comprising of 31 healthy controls, 24 diabetic patients with no clinically detectable retinopathy (NDR group), 26 patients with non-proliferative DR (NPDR group), and 20 patients with proliferative DR (PDR group), including 62 males and 49 females, average aged 61.65 ± 9.4. Retinal morphology was evaluated using spectral domain optical coherence tomography (SD-OCT), while retinal function was assessed using full-field electroretinogram (ffERG) to record the amplitudes and implicit time. The correlation between serum Trx, Txnip, and DR was analyzed using Spearman correlation analysis.
In the early stage of DR, there was no significant difference in macular retinal thickness between groups; in the PDR group, there was a significant increase compared to both the NDR and control groups, particularly in the central fovea ( < 0.0001). Additionally, the amplitude and implicit time of oscillatory potentials exhibited a significant difference between the NDR and control groups at an early stage of DR ( < 0.001). Furthermore, the amplitude of rod and cone ERG decreased significantly in the early stage of DR, while the implicit time began to decline in the NPDR stage. The serum levels of Trx and Txnip exhibited a positive correlation with the progression of DR ( = 0.851, 0.762). Conversely, a negative correlation was observed between the serum levels of Trx and Txnip and the amplitudes of ERG, while a positive correlation was observed with the implicit time of ERG.
The serum levels of Trx and Txnip exhibit a positive correlation with retinopathy associated with type 2 diabetes mellitus (T2DM), and thus may be utilized as a potential target for the timely diagnosis and treatment of DR.
探讨硫氧还蛋白（Trx）、硫氧还蛋白相互作用蛋白（Txnip）与糖尿病视网膜病变（DR）严重程度之间的关系。
本研究共纳入101只眼，包括31名健康对照者、24例无临床可检测视网膜病变的糖尿病患者（无糖尿病视网膜病变组）、26例非增殖性糖尿病视网膜病变患者（NPDR组）和20例增殖性糖尿病视网膜病变患者（PDR组），其中男性62例，女性49例，平均年龄61.65±9.4岁。使用光谱域光学相干断层扫描（SD-OCT）评估视网膜形态，同时使用全视野视网膜电图（ffERG）评估视网膜功能，记录其振幅和隐含时间。采用Spearman相关性分析血清Trx、Txnip与DR之间的相关性。
在糖尿病视网膜病变早期，各组黄斑视网膜厚度无显著差异；在增殖性糖尿病视网膜病变组中，与无糖尿病视网膜病变组和对照组相比，黄斑视网膜厚度显著增加，尤其是在中央凹处（<0.0001）。此外，在糖尿病视网膜病变早期，无糖尿病视网膜病变组与对照组的振荡电位振幅和隐含时间存在显著差异（<0.001）。此外，在糖尿病视网膜病变早期，视杆和视锥细胞视网膜电图的振幅显著降低，而隐含时间在非增殖性糖尿病视网膜病变阶段开始下降。血清Trx和Txnip水平与糖尿病视网膜病变的进展呈正相关（=0.851，0.762）。相反，血清Trx和Txnip水平与视网膜电图振幅呈负相关，与视网膜电图隐含时间呈正相关。
血清Trx和Txnip水平与2型糖尿病（T2DM）相关的视网膜病变呈正相关，因此可作为糖尿病视网膜病变早期诊断和治疗的潜在靶点。
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