血小板活化因子的构效关系。2. 消旋-1-O-十八烷基-2-O-乙酰基-3-O-[γ-(二甲基氨基)丙基]甘油

Structure-activity relationship in PAF-acether. 2. rac-1-O-Octadecyl-2-O-acetyl-3-O-[gamma-(dimethylamino)propyl]glycerol .

作者信息

Heymans F, Borrel M C, Broquet C, Lefort J, Godfroid J J

出版信息

J Med Chem. 1985 Aug;28(8):1094-6. doi: 10.1021/jm00146a019.

PMID:4020830

Abstract

Two products without phosphoryl groups, 1-O-octadecyl-2-O-acetyl-3-O-[gamma-(dimethylamino)propyl]glycerol and its quaternary salt, were synthesized from 1-O-octadecyl-2-O-benzylglycerol. In comparison with PAF-acether, they lost aggregating and bronchoconstrictive activities and did not show any antagonistic effects.

摘要

从1-O-十八烷基-2-O-苄基甘油合成了两种不含磷酰基的产物，1-O-十八烷基-2-O-乙酰基-3-O-[γ-(二甲基氨基)丙基]甘油及其季铵盐。与血小板活化因子（PAF-乙醚）相比，它们失去了聚集和支气管收缩活性，并且没有表现出任何拮抗作用。