Calabrese Edward J, Pressman Peter, Hayes A Wallace, Agathokleous Evgenios, Dhawan Gaurav, Kapoor Rachna, Parmar Japjee, Mssillou Ibrahim, Calabrese Vittorio
Department of Environmental Health, School of Public Health and Health Sciences, University of Massachusetts, Morrill I-N344, Amherst, MA, 01003, USA.
University of Maine, 5728 Fernald Hall, Room 201, Orono, ME, 04469, USA.
Biogerontology. 2025 Apr 10;26(2):90. doi: 10.1007/s10522-025-10230-1.
The present paper provides the first integrated assessment of the capacity of the flavonol, fisetin, to induce hormetic dose responses. Fisetin was shown to induce hormetic dose responses in cellular and in vivo animal model systems affecting a broad range of endpoints of potential therapeutic and public health significance across the entire lifespan. Fisetin was effective in slowing aging processes, acting as a senolytic agent in multiple organ systems, in an hormetic fashion. In addition, fisetin was broadly neuroprotective, including during fetal development, and preventing the toxicity of methylmercury. Since these findings indicate that fisetin may have the potential to induce multi-system chemoprotective effects, it indicates the need to better clarify the absorption and bioavailability of fisetin and ways to enhance its efficiency.
本文首次对黄酮醇非瑟酮诱导剂量效应的能力进行了综合评估。研究表明，非瑟酮在细胞和体内动物模型系统中可诱导剂量效应，影响整个生命周期中一系列具有潜在治疗和公共卫生意义的终点。非瑟酮能以剂量效应的方式有效减缓衰老过程，在多个器官系统中发挥促衰老细胞溶解剂的作用。此外，非瑟酮具有广泛的神经保护作用，包括在胎儿发育期间，并能预防甲基汞的毒性。由于这些发现表明非瑟酮可能具有诱导多系统化学保护作用的潜力，这表明有必要更好地阐明非瑟酮的吸收和生物利用度以及提高其效率的方法。
