Taylor D, Perri S F
Am J Vet Res. 1977 Jan;38(1):51-4.
The severity of Platynosomum concinnum infection in cats experimentally infected with 125 flukes (small dose) and 1,000 flukes (large dose) was determined by monitoring clinical signs and hematologic, serum biochemical, and pathologic changes during the infection. All cats (8/8) with a small fluke burden and 3 of 8 cats with a large burden remained clinically asymptomatic, whereas 60% of the cats given large doses had mild signs of inappetence and lethargy. Eosinophilia, peaking 4 to 5 months after infection, was present in all parasitized cats. During the early stages of platynosomiasis, a transient but substantial increase in aspartate aminotransferase and alanine aminotransferase activities was observed in cats given small and large doses. These observations agreed with gross and histopathologic observations, which included enlargement of the gallbladder and biliary ducts, with leukocyte infiltration, adenomatous hyperplasia, and fibrosis of the ductal areas.
通过监测感染期间的临床症状、血液学、血清生化和病理变化，确定了实验性感染125条吸虫（小剂量）和1000条吸虫（大剂量）的猫体内扁体吸虫感染的严重程度。所有感染少量吸虫的猫（8/8）和8只感染大量吸虫的猫中的3只在临床上没有症状，而60%接受大剂量感染的猫有轻度食欲不振和嗜睡症状。所有受寄生虫感染的猫均出现嗜酸性粒细胞增多，在感染后4至5个月达到峰值。在扁体吸虫病的早期阶段，给予小剂量和大剂量感染的猫均观察到天冬氨酸转氨酶和丙氨酸转氨酶活性短暂但显著增加。这些观察结果与大体和组织病理学观察结果一致，后者包括胆囊和胆管肿大，伴有白细胞浸润、腺瘤样增生和导管区域纤维化。
