Deng Yuanyuan, Hao Zejin, Chen Wen, Zhang Junping, Zou Yun, Zhang Jie, Xi Yanhua, Xu Jixiong
Department of Endocrinology and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang,Jiangxi 330006, PR China; Jiangxi Clinical Research Center for Endocrine and Metabolic Disease, Nanchang 330006, PR China; Jiangxi Branch of National Clinical Research Center for Metabolic Disease, Nanchang 330006, PR China.
Department of Endocrinology and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang,Jiangxi 330006, PR China; Jiangxi Clinical Research Center for Endocrine and Metabolic Disease, Nanchang 330006, PR China; Jiangxi Branch of National Clinical Research Center for Metabolic Disease, Nanchang 330006, PR China.
J Psychosom Res. 2025 May;192:112124. doi: 10.1016/j.jpsychores.2025.112124. Epub 2025 Apr 3.
Many patients with Graves' disease (GD) also suffer from mental disorders in clinical practice, but their causal relationship remains unclear. This study aims to investigate the causal relationship between GD and common mental disorders using a bidirectional Mendelian randomization (MR)approach.
We derived genome-wide association study (GWAS) data for common mental disorders, including major depressive disorder (MDD), anxiety disorders, bipolar disorder, and attention-deficit/hyperactivity disorder (ADHD), from the Psychiatric Genomics Consortium consortium. GWAS data for GD were obtained from the FinnGen consortium. Subsequently, a bidirectional MR analysis was conducted, with the inverse-variance weighted (IVW) methods as the primary MR analysis method. Sensitivity analysis used Cochran's Q test, MR-Egger intercept test, and leave-one-out method.
IVW results in MR demonstrated a positive association between genetic susceptibility to GD and bipolar disorder (OR = 1.073, 95 % CI: 1.042-1.105, p = 2.882 × 10). Similar causal estimates were obtained through MR-Egger regression and the weighted median method. Additionally, both Cochran's Q test and MR-Egger intercept test indicated no evidence of heterogeneity or pleiotropy. However, no causal associations were demonstrated between GD and MDD, anxiety disorders, or ADHD. Furthermore, a causal relationship between genetic susceptibility to common mental disorders and GD was not evidenced.
This bidirectional MR study supports the role of GD in the causal association with an increased risk of bipolar disorder, which guides us to pay attention to the mental diseases of GD patients in the clinic.
在临床实践中，许多格雷夫斯病（GD）患者也患有精神障碍，但其因果关系仍不明确。本研究旨在使用双向孟德尔随机化（MR）方法探讨GD与常见精神障碍之间的因果关系。
我们从精神基因组学联盟获取了常见精神障碍的全基因组关联研究（GWAS）数据，包括重度抑郁症（MDD）、焦虑症、双相情感障碍和注意力缺陷多动障碍（ADHD）。GD的GWAS数据来自芬兰基因组联盟。随后，进行了双向MR分析，以逆方差加权（IVW）方法作为主要的MR分析方法。敏感性分析采用 Cochr an Q检验、MR-Egger截距检验和留一法。
MR中的IVW结果显示，GD的遗传易感性与双相情感障碍之间存在正相关（OR = 1.073，95%CI：1.042 - 1.105，p = 2.882×10）。通过MR-Egger回归和加权中位数方法获得了相似的因果估计。此外， Cochr an Q检验和MR-Egger截距检验均未显示异质性或多效性的证据。然而，GD与MDD、焦虑症或ADHD之间未显示因果关联。此外，也没有证据表明常见精神障碍的遗传易感性与GD之间存在因果关系。
这项双向MR研究支持GD在与双相情感障碍风险增加的因果关联中的作用，这指导我们在临床上关注GD患者的精神疾病。
