在单细胞分辨率下解析胃癌中的基因调控
Deciphering genetic regulation at single-cell resolution in gastric cancer.
作者信息
Chen Chengxuan, Han Leng
机构信息
Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Brown Center for Immunotherapy, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
出版信息
Cell Genom. 2025 Apr 9;5(4):100846. doi: 10.1016/j.xgen.2025.100846.
Understanding cell-type-specific genetic regulation in gastric cancer is essential for uncovering disease susceptibility. By performing single-cell eQTL mapping in gastric tissues, Bian et al. identified previously uncharacterized regulatory genetic mechanisms, risk genes, and co-localization signals associated with gastric cancer susceptibility, providing insights into its pathogenesis and potential therapeutic approaches.
了解胃癌中细胞类型特异性的基因调控对于揭示疾病易感性至关重要。通过在胃组织中进行单细胞eQTL定位，卞等人确定了与胃癌易感性相关的先前未被表征的调控基因机制、风险基因和共定位信号，为其发病机制和潜在治疗方法提供了见解。
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