Fan Huijuan, Li Nan, Zhang Xingguang, Xu Wei, Zhang Wencheng, Ding Yangjuan, Li Lingjian, Liu Taotao, Xia Shihai
Tianjin University of Traditional Chinese Medicine, Tianjin 301617, People's Republic of China.
Department of Gastroenterology, Characteristic Medical Center of the Chinese People's Armed Police Force, Tianjin Key Laboratory of Hepatopancreatic Fiberosis and Molecular Diagnosis & Treatment, Tianjin, 300162, People's Republic of China.
Biomed Mater. 2025 Apr 22;20(3). doi: 10.1088/1748-605X/adcb7d.
Pancreatic duct strictures, which can arise from trauma, inflammation, or malignancy, often result in complications such as duct obstruction, pancreatic parenchymal hypertension, and ischemia. Endoscopic stenting is an effective therapeutic approach for managing these strictures. However, traditional plastic pancreatic duct stents fail to conform to the physiological curvature of the pancreas, while metal pancreatic duct stents with flared ends reduce migration but are associated with complications such as de novo strictures. Additionally, plastic and metal pancreatic duct stents require surgical removal. Whereas biodegradable pancreatic duct stents present a promising alternative due to their superior biocompatibility and ability to decompose into non-toxic materials, potentially eliminating the need for additional surgeries. Despite these advantages, biodegradable pancreatic duct stents remain in the experiment stage. This review assesses current materials of pancreatic duct stents, and emphasizes recent advancements in biodegradable options and emerging trends in clinical applications.
胰腺导管狭窄可由创伤、炎症或恶性肿瘤引起，常导致诸如导管阻塞、胰腺实质高压和缺血等并发症。内镜支架置入术是治疗这些狭窄的有效方法。然而，传统的塑料胰腺导管支架不能顺应胰腺的生理曲度，而带喇叭口的金属胰腺导管支架虽能减少移位，但会引发诸如新生狭窄等并发症。此外，塑料和金属胰腺导管支架都需要手术取出。而可生物降解的胰腺导管支架因其卓越的生物相容性以及分解为无毒材料的能力，成为一种有前景的替代方案，有可能无需额外手术。尽管有这些优势，可生物降解的胰腺导管支架仍处于实验阶段。本文综述评估了当前胰腺导管支架的材料，并着重介绍了可生物降解材料的最新进展以及临床应用的新趋势。
