Zhang Jiayu, Weng Shoutao, Fan Zaiwei, Hu Dongyang, Le Jiadi, Sheng Kongsheng
Department of ECG, Sir Run Run Shaw Hospital, Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University, Hangzhou, China.
Department of Orthopaedics, Key Laboratory of Orthopaedics of Zhejiang Province, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Cell Signal. 2025 Aug;132:111796. doi: 10.1016/j.cellsig.2025.111796. Epub 2025 Apr 8.
Migrasomes are vesicular structures that form on elongated tethers originating from the tips or junctions of cellular tails during migration. These organelles, named for their vesicle rich lumen and release during cell movement, have gained attention for their role in intercellular communication and signal transduction. Migrasome formation is closely associated with the dynamic and active movement of cells, as well as with the intrinsic properties of cells and the extracellular microenvironment under various pathophysiological conditions. This review provides a comprehensive overview of migrasome dynamics, examining the mechanisms and distinct features of nanoscale vesicle-mediated intercellular signaling. It also highlights the influence of microscopic secretory factors on migrasome generation and formation. By comparing migrasomes with other active extracellular vesicles, this review highlights the advantages of migrasomes and addresses future challenges.
迁移小体是在细胞迁移过程中，在源自细胞尾部尖端或连接处的细长系链上形成的囊泡结构。这些细胞器因其富含囊泡的内腔以及在细胞运动过程中的释放而得名，因其在细胞间通讯和信号转导中的作用而受到关注。迁移小体的形成与细胞的动态和活跃运动密切相关，也与各种病理生理条件下细胞的内在特性和细胞外微环境有关。本文综述全面概述了迁移小体动力学，研究了纳米级囊泡介导的细胞间信号传导的机制和独特特征。它还强调了微观分泌因子对迁移小体产生和形成的影响。通过将迁移小体与其他活性细胞外囊泡进行比较，本文综述突出了迁移小体的优势并探讨了未来的挑战。
