Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Inflammatory Bowel Disease Research Center, Shanghai Institute of Digestive Disease, 160# Pu Jian Ave, Shanghai 200127, China.
Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Inflammatory Bowel Disease Research Center, Shanghai Institute of Digestive Disease, 160# Pu Jian Ave, Shanghai 200127, China.
Acta Biomater. 2024 Nov;189:88-102. doi: 10.1016/j.actbio.2024.09.013. Epub 2024 Sep 14.
Migrasomes are recently identified extracellular vesicles and organelles formed in conjunction with cell migration. They are situated at the rear of migrating cells, exhibit a circular or elliptical membrane-enclosed structure, and function as a new organelle. Migrasomes selectively sort intercellular components, mediating a cell migration-dependent release mechanism known as migracytosis and modulating cell-cell communication. Accumulated evidence clarifies migrasome formation processes and indicates their diverse functional roles. Migrasomes may also be potentially correlated with the occurrence, progression, and prognosis of certain diseases. Migrasomes' involvement in physiological and pathological processes highlights their potential for expanding our understanding of biological procedures and as a target in clinical therapy. However, the precise mechanisms and full extent of their involvement in immunity, barriers, and diseases remain unclear. This review aimed to provide a comprehensive overview of the roles of migrasomes in human immunity and barriers, in addition to providing insights into their impact on human diseases. STATEMENT OF SIGNIFICANCE: Migrasomes, newly identified extracellular vesicles and organelles, form during cell migration and are located at the rear of migrating cells. These circular or elliptical structures mediate migracytosis, selectively sorting intercellular components and modulating cell-cell communication. Evidence suggests diverse functional roles for migrasomes, including potential links to disease occurrence, progression, and prognosis. Their involvement in physiological and pathological processes highlights their significance in understanding biological procedures and potential clinical therapies. However, their exact mechanisms in immunity, barriers, and diseases remain unclear. This review provides an overview of migrasomes' roles in human immunity and barriers, and their impact on diseases.
迁移小体是最近发现的细胞外囊泡和细胞器，与细胞迁移有关。它们位于迁移细胞的后端，呈现圆形或椭圆形的膜封闭结构，作为一种新的细胞器发挥作用。迁移小体能够选择性地分拣细胞间成分，介导一种称为迁移胞吐作用的细胞迁移依赖性释放机制，并调节细胞间通讯。越来越多的证据阐明了迁移小体的形成过程，并表明其具有多种功能作用。迁移小体也可能与某些疾病的发生、发展和预后有关。迁移小体在生理和病理过程中的作用突出了它们在扩展我们对生物过程的理解以及作为临床治疗靶点方面的潜力。然而，其在免疫、屏障和疾病中的确切机制和全部作用尚不清楚。本综述旨在全面概述迁移小体在人类免疫和屏障中的作用，并深入了解它们对人类疾病的影响。
迁移小体是新发现的细胞外囊泡和细胞器，在细胞迁移过程中形成，位于迁移细胞的后端。这些圆形或椭圆形结构介导迁移胞吐作用，选择性地分拣细胞间成分并调节细胞间通讯。有证据表明迁移小体具有多种功能作用，包括与疾病的发生、发展和预后有关的潜在联系。它们在生理和病理过程中的作用突出了它们在理解生物过程和潜在临床治疗方面的重要性。然而，其在免疫、屏障和疾病中的确切机制尚不清楚。本综述全面概述了迁移小体在人类免疫和屏障中的作用及其对疾病的影响。
