Hao Xu, Feng Yilin, Lu Anqi, Sun Ying, Xia Jinchan, Mei Xue, Feng Long, Jiang Min, Wang Baiyan, Yang Huitong
Medical College of Henan University of Chinese Medicine, Zhengzhou 450046, China.
Zhongguo Fei Ai Za Zhi. 2025 Mar 20;28(3):201-212. doi: 10.3779/j.issn.1009-3419.2025.106.06.
Neutrophil extracellular traps (NETs), intricate reticular structures released by activated neutrophils, play a pivotal regulatory role in the pathogenesis of malignant tumors. Lung cancer is one of the most prevalent malignancies globally, with persistently high incidence and mortality rates. Recent studies have revealed that NETs dynamically modulate the tumor microenvironment through unique pathological mechanisms, exhibiting complex immunoregulatory characteristics during the progression of lung cancer, and this discovery has increasingly become a focal point in tumor immunology research. This paper provides a comprehensive review of the latest advancements in NETs research related to lung cancer, offering an in-depth analysis of their impact on lung cancer progression, their potential diagnostic value, and the current state of research on targeting NETs for lung cancer prevention and treatment. The aim is to propose novel strategies to enhance therapeutic outcomes and improve the prognosis for lung cancer patients. .
中性粒细胞胞外诱捕网（NETs）是活化的中性粒细胞释放的复杂网状结构，在恶性肿瘤的发病机制中起关键调节作用。肺癌是全球最常见的恶性肿瘤之一，发病率和死亡率持续居高不下。最近的研究表明，NETs通过独特的病理机制动态调节肿瘤微环境，在肺癌进展过程中表现出复杂的免疫调节特征，这一发现日益成为肿瘤免疫学研究的焦点。本文全面综述了与肺癌相关的NETs研究的最新进展，深入分析了它们对肺癌进展的影响、潜在的诊断价值以及针对NETs进行肺癌预防和治疗的研究现状。目的是提出新的策略以提高治疗效果并改善肺癌患者的预后。
