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亨廷顿舞蹈症与牙科:病因、临床表现、症状性药物治疗及牙科管理综述

Huntington's Disease and Dentistry: A Review of Its Etiology, Clinical Presentation, Symptomatic Pharmacotherapy, and Dental Management.

作者信息

Duble Hanad, Ouanounou Aviv

机构信息

Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.

Associate Professor, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.

出版信息

Spec Care Dentist. 2025 Mar-Apr;45(2):e70024. doi: 10.1111/scd.70024.

Abstract

AIMS

Patients with Huntington's Disease (HD) seeking dental care often present with poor oral health. Dentists often report that few protocols exist and there is a lack of understanding on how to manage these patients in the dental office. The aim of this review is to discuss the etiology and pathophysiology, clinical presentation, and management of this condition primarily from the dental perspective.

METHODS

A detailed literature review was conducted including articles searched on PubMed and Google Scholar using relevant keywords. Inclusion criteria prioritized studies based on relevance to oral care and HD with topics including caregiver-assisted oral hygiene, fluoride, dental preventative approaches, and case studies.

RESULTS

Research reveals the significant oral health issues patients with HD suffer from including dysphagia, xerostomia, and a high caries risk. Studies illustrate the need for tailored care emphasizing long term treatment planning, preventive, and clinically relevant approaches.

CONCLUSION

This review presents the importance of a proactive, multidisciplinary strategy to dental care in HD patients. Early preventive strategies can greatly postpone the decline of oral health in this population. Future studies should focus on a conclusive dental care guideline, caregiver education initiatives, and improving access to care in this patient population.

摘要

目的

寻求牙科护理的亨廷顿舞蹈症(HD)患者往往口腔健康状况不佳。牙医经常报告说,针对这类患者的治疗方案很少,并且对于如何在牙科诊所治疗这类患者缺乏了解。本综述的目的主要从牙科角度探讨这种疾病的病因、病理生理学、临床表现及治疗方法。

方法

进行了详细的文献综述,包括使用相关关键词在PubMed和谷歌学术上搜索的文章。纳入标准优先考虑与口腔护理和HD相关的研究,主题包括护理人员协助的口腔卫生、氟化物、牙科预防方法及案例研究。

结果

研究表明,HD患者存在严重的口腔健康问题,包括吞咽困难、口干和高龋齿风险。研究表明需要采取量身定制的护理措施,强调长期治疗计划、预防性和临床相关方法。

结论

本综述阐述了对HD患者采取积极主动的多学科牙科护理策略的重要性。早期预防策略可大大延缓该人群口腔健康的下降。未来的研究应侧重于制定结论性的牙科护理指南、护理人员教育倡议以及改善该患者群体获得护理的机会。

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