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亨廷顿舞蹈症与牙科:病因、临床表现、症状性药物治疗及牙科管理综述

Huntington's Disease and Dentistry: A Review of Its Etiology, Clinical Presentation, Symptomatic Pharmacotherapy, and Dental Management.

作者信息

Duble Hanad, Ouanounou Aviv

机构信息

Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.

Associate Professor, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.

出版信息

Spec Care Dentist. 2025 Mar-Apr;45(2):e70024. doi: 10.1111/scd.70024.

DOI:10.1111/scd.70024
PMID:40211432
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11985692/
Abstract

AIMS

Patients with Huntington's Disease (HD) seeking dental care often present with poor oral health. Dentists often report that few protocols exist and there is a lack of understanding on how to manage these patients in the dental office. The aim of this review is to discuss the etiology and pathophysiology, clinical presentation, and management of this condition primarily from the dental perspective.

METHODS

A detailed literature review was conducted including articles searched on PubMed and Google Scholar using relevant keywords. Inclusion criteria prioritized studies based on relevance to oral care and HD with topics including caregiver-assisted oral hygiene, fluoride, dental preventative approaches, and case studies.

RESULTS

Research reveals the significant oral health issues patients with HD suffer from including dysphagia, xerostomia, and a high caries risk. Studies illustrate the need for tailored care emphasizing long term treatment planning, preventive, and clinically relevant approaches.

CONCLUSION

This review presents the importance of a proactive, multidisciplinary strategy to dental care in HD patients. Early preventive strategies can greatly postpone the decline of oral health in this population. Future studies should focus on a conclusive dental care guideline, caregiver education initiatives, and improving access to care in this patient population.

摘要

目的

寻求牙科护理的亨廷顿舞蹈症(HD)患者往往口腔健康状况不佳。牙医经常报告说,针对这类患者的治疗方案很少,并且对于如何在牙科诊所治疗这类患者缺乏了解。本综述的目的主要从牙科角度探讨这种疾病的病因、病理生理学、临床表现及治疗方法。

方法

进行了详细的文献综述,包括使用相关关键词在PubMed和谷歌学术上搜索的文章。纳入标准优先考虑与口腔护理和HD相关的研究,主题包括护理人员协助的口腔卫生、氟化物、牙科预防方法及案例研究。

结果

研究表明,HD患者存在严重的口腔健康问题,包括吞咽困难、口干和高龋齿风险。研究表明需要采取量身定制的护理措施,强调长期治疗计划、预防性和临床相关方法。

结论

本综述阐述了对HD患者采取积极主动的多学科牙科护理策略的重要性。早期预防策略可大大延缓该人群口腔健康的下降。未来的研究应侧重于制定结论性的牙科护理指南、护理人员教育倡议以及改善该患者群体获得护理的机会。

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Huntington's Disease and Dentistry: A Review of Its Etiology, Clinical Presentation, Symptomatic Pharmacotherapy, and Dental Management.亨廷顿舞蹈症与牙科:病因、临床表现、症状性药物治疗及牙科管理综述
Spec Care Dentist. 2025 Mar-Apr;45(2):e70024. doi: 10.1111/scd.70024.
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本文引用的文献

1
Reflexive and voluntary saccadic eye movements as biomarker of Huntington's Disease.反射性和随意性眼球跳动可作为亨廷顿病的生物标志物。
Neurol Neurochir Pol. 2024;58(3):323-330. doi: 10.5603/pjnns.95190. Epub 2024 May 31.
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Systemic Symptoms in Huntington's Disease: A Comprehensive Review.亨廷顿病的系统症状:全面综述。
Mov Disord Clin Pract. 2024 May;11(5):453-464. doi: 10.1002/mdc3.14029. Epub 2024 Mar 26.
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Somatic CAG repeat instability in intermediate alleles of the HTT gene and its potential association with a clinical phenotype.HTT 基因中间等位基因的体细胞 CAG 重复不稳定及其与临床表型的潜在关联。
Eur J Hum Genet. 2024 Jul;32(7):770-778. doi: 10.1038/s41431-024-01546-6. Epub 2024 Mar 4.
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Mild cognitive impairment in Huntington's disease: challenges and outlooks.亨廷顿病患者的轻度认知障碍:挑战与展望。
J Neural Transm (Vienna). 2024 Apr;131(4):289-304. doi: 10.1007/s00702-024-02744-8. Epub 2024 Jan 24.
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Long-term antipsychotic use, orthostatic hypotension and falls in older adults with Alzheimer's disease.长期使用抗精神病药物与老年阿尔茨海默病患者直立性低血压和跌倒的关系。
Eur Geriatr Med. 2024 Apr;15(2):527-537. doi: 10.1007/s41999-023-00910-x. Epub 2024 Jan 2.
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Centrally and peripherally altered glucose transporters: is it time to revisit energy deficiency as a potential treatment strategy in Huntington's disease?中枢和外周葡萄糖转运体的改变:是时候重新审视能量缺乏作为亨廷顿舞蹈病潜在治疗策略了吗?
EBioMedicine. 2023 Dec;98:104882. doi: 10.1016/j.ebiom.2023.104882. Epub 2023 Nov 17.
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High-viscosity glass-ionomer cement or composite resin for restorations in posterior permanent teeth? A systematic review and meta-analyses.高粘度玻璃离子水门汀或复合树脂用于后牙永久修复?系统评价和荟萃分析。
J Dent. 2023 Oct;137:104629. doi: 10.1016/j.jdent.2023.104629. Epub 2023 Jul 26.
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The development of functional connectivity within the dorsal striatum from early childhood to adulthood.背侧纹状体功能连接从儿童早期到成年期的发展。
Dev Cogn Neurosci. 2023 Jun;61:101258. doi: 10.1016/j.dcn.2023.101258. Epub 2023 May 22.
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How can general dental practitioners help in the management of sleep apnoea?一般牙医如何帮助管理睡眠呼吸暂停?
Br Dent J. 2023 Apr;234(7):505-509. doi: 10.1038/s41415-023-5684-1. Epub 2023 Apr 14.
10
Chorea me a river: depression in Huntington's disease as an exemplar of precision medicine.舞蹈症如河流般困扰着我:亨廷顿舞蹈病中的抑郁症作为精准医学的一个范例
Brain Commun. 2022 Nov 9;4(6):fcac294. doi: 10.1093/braincomms/fcac294. eCollection 2022.