Xu Zhe, Dong Yurong, Cui Kun, Hu Bin, Lu Ying, Liu Xiangjie, Shahzad Asif, Zhang Jinshan, Duan Qiuxin, Bai Ziyuan, Peng Dongmei, Xia Jiaojiao, Liu Wenjing, Teng Zhuoran, Yang Zhe, Zhang Qiao
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Kunming Medical University, Yunnan, Kunming 650500, China.
School of Basic Medical Sciences, Qujing Medical College, Yunnan, Qujing 655100, China.
iScience. 2025 Mar 11;28(4):112183. doi: 10.1016/j.isci.2025.112183. eCollection 2025 Apr 18.
Renal cell carcinoma (RCC), particularly clear cell RCC (ccRCC), has seen rising incidence and mortality rates. Early detection remains difficult due to nonspecific symptoms, often leading to diagnoses at advanced stages and unfavorable prognoses. Current treatments, including surgery, targeted therapies, and immunotherapies, face limitations such as adverse reactions, drug resistance, and immune evasion. This review discusses the role of circular RNAs (circRNAs) and their involvement in the circRNA/miRNA/mRNA axis during RCC progression. As competitive endogenous RNAs (ceRNAs), circRNAs regulate gene expression and cellular processes, including proliferation, metastasis, apoptosis, and drug resistance. Furthermore, we explore the impact of circRNAs on tumor metabolic reprogramming and their influence on the immune microenvironment. We also summarize the clinical prospects, challenges, and future directions in this field. A comprehensive understanding of these complex interactions may provide new insights into the diagnosis and treatment of RCC, ultimately overcoming existing challenges and improving patient outcomes.
肾细胞癌（RCC），尤其是透明细胞肾细胞癌（ccRCC）的发病率和死亡率一直在上升。由于症状不具特异性，早期检测仍然困难，这常常导致在晚期才得以诊断，预后不佳。目前的治疗方法，包括手术、靶向治疗和免疫治疗，都面临着诸如不良反应、耐药性和免疫逃逸等局限性。本综述讨论了环状RNA（circRNA）的作用及其在RCC进展过程中参与circRNA/miRNA/mRNA轴的情况。作为竞争性内源性RNA（ceRNA），circRNA调节基因表达和细胞过程，包括增殖、转移、凋亡和耐药性。此外，我们探讨了circRNA对肿瘤代谢重编程的影响及其对免疫微环境的影响。我们还总结了该领域的临床前景、挑战和未来方向。对这些复杂相互作用的全面理解可能为RCC的诊断和治疗提供新的见解，最终克服现有挑战并改善患者预后。
