Wang Mingming, Zhang Jiayuan, Li Hanyue, Li Yini, Li Zhigang
Police Basic Skills Teaching Department, Sichuan Police College, Luzhou, Sichuan, China.
School of Physical Education, Southwest Medical University, Luzhou, Sichuan, China.
Front Bioeng Biotechnol. 2025 Mar 27;13:1492811. doi: 10.3389/fbioe.2025.1492811. eCollection 2025.
Tendon injury is one of the most common musculoskeletal disorders that severely affect patients' daily lives. Unfortunately, naturally healed tendons exhibit poor quality, as they have very limited regenerative ability. Recently, therapeutic strategies involving the administration of growth factors have been advocated to enhance tendon regenerative healing. Growth factors are peptide-signaling molecules that elicit biological functions such as cell proliferation, migration, and differentiation by acting through a complex organization of cell surface receptors and activating intracellular signaling pathways. Insulin-like growth factor-1(IGF-1) represents one such factor that has shown promising effects for enhancing tendon regenerative healing and animal models. However, it is disappointing that IGF-1 has not been shown to play a very significant role in promoting tendon healing in clinical trials, which could reflect our poor understanding of the molecular mechanisms by which IGF-1 is involved in promoting tendon regenerative healing. Therefore, in this review, we summarized the roles and mechanisms of IGF-1 for enhancing tendon regenerative healing. Nevertheless, much work is still needed to optimize its effectiveness.
肌腱损伤是最常见的肌肉骨骼疾病之一，严重影响患者的日常生活。不幸的是，自然愈合的肌腱质量较差，因为它们的再生能力非常有限。最近，有人提倡采用施用生长因子的治疗策略来促进肌腱的再生愈合。生长因子是肽信号分子，通过细胞表面受体的复杂组织起作用并激活细胞内信号通路，从而引发细胞增殖、迁移和分化等生物学功能。胰岛素样生长因子-1（IGF-1）就是这样一种因子，在增强肌腱再生愈合方面对动物模型显示出有前景的效果。然而，令人失望的是，在临床试验中，IGF-1尚未被证明在促进肌腱愈合方面发挥非常显著的作用，这可能反映出我们对IGF-1参与促进肌腱再生愈合的分子机制了解不足。因此，在本综述中，我们总结了IGF-1在增强肌腱再生愈合中的作用和机制。尽管如此，仍需要做大量工作来优化其有效性。
