Guo Xue, Li Jianhong, Xu Jing, Zhang Leiting, Huang Chen, Nie Yuqiang, Zhou Youlian
Department of Gastroenterology and Hepatology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, China.
Department of Gastroenterology and Hepatology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, China.
Gut Microbes. 2025 Dec;17(1):2490207. doi: 10.1080/19490976.2025.2490207. Epub 2025 Apr 11.
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is considered significant global health concerns worldwide. Many studies have demonstrated that environmental and dietary factors influence the gut microbiota, which in turn orchestrates the host immune responses. These interactions are also involved in complex metabolic processes that contribute to the pathogenesis of IBD. Furthermore, recent studies in genomics and metabolomics have unveiled the intricate relationship between microbial influencers and host epigenetics. The dynamics of gut microbiota and its metabolites intricately align with DNA methylation, histone methylation, lactylation, glycosylation, and non-coding RNAs, which are key players in epigenetics. Here, we summarize and discuss the complex interplay among gut microbiota, epigenetics, and environmental and dietary factors, and their impact on the pathogenesis of IBD. Furthermore, we highlight the importance of multi-omics technologies in dissecting the host-microbe interactions in IBD, potentially offering a framework for developing effective treatment strategies.
炎症性肠病（IBD），包括克罗恩病和溃疡性结肠炎，被认为是全球范围内重大的健康问题。许多研究表明，环境和饮食因素会影响肠道微生物群，而肠道微生物群反过来又会协调宿主的免疫反应。这些相互作用还参与了导致IBD发病机制的复杂代谢过程。此外，最近在基因组学和代谢组学方面的研究揭示了微生物影响因素与宿主表观遗传学之间的复杂关系。肠道微生物群及其代谢产物的动态变化与DNA甲基化、组蛋白甲基化、乳酰化、糖基化以及非编码RNA密切相关，这些都是表观遗传学的关键因素。在此，我们总结并讨论肠道微生物群、表观遗传学以及环境和饮食因素之间的复杂相互作用，以及它们对IBD发病机制的影响。此外，我们强调了多组学技术在剖析IBD中宿主与微生物相互作用方面的重要性，这可能为制定有效的治疗策略提供一个框架。
