Togawa Go, Lewis Melissa J, Were Stephen R, Bentley R Timothy, Thomovsky Stephanie A
Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana, USA.
J Vet Intern Med. 2025 May-Jun;39(3):e70092. doi: 10.1111/jvim.70092.
Approximately 50%-60% of paraplegic deep pain negative (DPN) dogs secondary to thoracolumbar intervertebral disc extrusion (TL-IVDE) recover ambulation after surgery. Mean F-wave duration has been associated with injury severity in TL-IVDE in dogs, but the relationship to outcome is unknown.
Evaluate the prognostic utility of F-waves in DPN dogs secondary to TL-IVDE treated surgically.
Thirty client-owned, acutely paraplegic DPN dogs secondary to TL-IVDE were managed surgically.
Multi-center prospective and observational study. F-waves were performed at baseline (within 24 h post-operatively), 2-4 weeks and 3 months post-operatively. Outcome was categorized as successful or unsuccessful, with success defined as independent ambulation at 3 months post-operatively. F-wave variables were compared between dogs with a successful or unsuccessful outcome and over time using generalized estimating equations. Receiver-operating characteristic curves were generated for baseline F-wave variables.
F-waves were well-tolerated in all dogs. Of 30 enrolled dogs, 12 dogs had a successful outcome, 10 dogs were unsuccessful, and 8 dogs were removed from outcome analysis (3 progressive myelomalacia, 1 severe spinal shock, 2 technical error, and 2 unknown outcome). Baseline mean F-wave duration (displayed as median (range)) was longer in unsuccessful dogs (31.7 (11.4-60.8) ms) versus successful dogs (19.6 (10.8-27.3) ms), p = 0.003. Mean F-wave duration > 28.5 ms was 70% sensitive (95% confidence interval (CI): 40%-100%) and 100% specific (95% CI: 100%-100%) in predicting an unsuccessful outcome.
F-waves performed shortly post-operatively could aid in predicting outcomes in DPN dogs secondary to TL-IVDE treated surgically.
继发于胸腰椎椎间盘突出症（TL-IVDE）的截瘫性深部疼痛阴性（DPN）犬中，约50%-60%在手术后恢复行走能力。平均F波持续时间与犬TL-IVDE的损伤严重程度相关，但与预后的关系尚不清楚。
评估F波对手术治疗的继发于TL-IVDE的DPN犬的预后价值。
30只由客户拥有的、继发于TL-IVDE的急性截瘫DPN犬接受了手术治疗。
多中心前瞻性观察研究。在基线（术后24小时内）、术后2-4周和3个月时进行F波检查。结果分为成功或不成功，成功定义为术后3个月独立行走。使用广义估计方程比较成功或不成功结果的犬之间以及随时间变化的F波变量。为基线F波变量生成受试者操作特征曲线。
所有犬对F波检查耐受性良好。在30只纳入的犬中，12只犬结果成功，10只犬结果不成功，8只犬被排除在结果分析之外（3只进行性脊髓软化，1只严重脊髓休克，2只技术失误，2只结果不明）。不成功犬的基线平均F波持续时间（以中位数（范围）表示）长于成功犬（31.7（11.4-60.8）毫秒对19.6（10.8-27.3）毫秒），p = 0.003。平均F波持续时间>28.5毫秒在预测不成功结果时敏感性为70%（95%置信区间（CI）：40%-100%），特异性为100%（95%CI：100%-100%）。
术后不久进行的F波检查有助于预测手术治疗的继发于TL-IVDE的DPN犬的预后。
