Machado Raiana Scerni, de Sousa Ivanildo Pedro, das Chagas Júnior Wanderley Dias, Ferreira James Lima, Lopes Daniela Pereira, Justino Maria Cleonice Aguiar, Tavares Fernando Neto
Laboratory of Virology and Molecular Parasitology, Oswaldo Cruz Foundation-Fiocruz, Oswaldo Cruz Institute, 21040-900, Rio de Janeiro, Brazil.
Postgraduate Program in Tropical Medicine, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
Arch Virol. 2025 Apr 11;170(5):99. doi: 10.1007/s00705-025-06278-6.
Globally, coxsackievirus A6 (CVA6) is a major cause of hand, foot, and mouth disease (HFMD) outbreaks, although studies on its evolutionary and transmission dynamics are limited. Here, we analyzed samples from atypical HFMD cases in Brazil. Enteroviruses were detected in 49.2% (156/317) of the specimens, with CVA6 being the primary pathogen. Phylogenetic analysis based on VP1 gene sequences revealed that Brazilian CVA6 isolates belonged to the lineage D3 and were divided into two distinct clades from different regions. Temporal analysis indicated that the most recent common ancestor dates back 72 years and that there has been stable coevolution of genotypes. These findings shed light on the epidemiological dynamics of CVA6 and highlight the importance of surveillance of atypical HFMD cases.
在全球范围内，柯萨奇病毒A6（CVA6）是手足口病（HFMD）疫情的主要病因，尽管对其进化和传播动态的研究有限。在此，我们分析了巴西非典型手足口病病例的样本。在49.2%（156/317）的标本中检测到肠道病毒，其中CVA6是主要病原体。基于VP1基因序列的系统发育分析表明，巴西的CVA6分离株属于D3谱系，并分为来自不同地区的两个不同分支。时间分析表明，最近的共同祖先可追溯到72年前，并且基因型一直处于稳定的共同进化状态。这些发现揭示了CVA6 的流行病学动态，并强调了监测非典型手足口病病例的重要性。
