Okada Genya, Matsumoto Yoshinari, Habu Daiki, Matsuda Yasunori, Lee Shigeru, Osugi Harushi
Department of Health Sciences, Prefectural University of Hiroshima, Hiroshima, Japan.
Department of Nutrition, Graduate School of Human Life and Ecology, Osaka Metropolitan University, Habikino-shi, Osaka, Japan.
Nutr Clin Pract. 2025 Oct;40(5):1178-1186. doi: 10.1002/ncp.11299. Epub 2025 Apr 11.
Dual-energy X-ray absorptiometry and bioelectrical impedance analysis (BIA) are used to measure appendicular skeletal muscle mass (ASM). However, these two methods can be contraindicated in some cases. Therefore, equations have been developed to predict ASM using anthropometric parameters, which is a less expensive and more feasible approach. This study evaluated the correlation between the predicted ASM calculated using a previously reported prediction equation and the actual ASM measured using BIA. Moreover, we determined their degree of agreement in diagnosing sarcopenia in patients with esophageal cancer.
From a previous study involving 119 patients with esophageal cancer, perioperative anthropometric parameters (height, weight, waist and circumference), and grip strength (GS) were obtained to calculate ASM in Japanese participants using a previously reported prediction equation (Furushima equation). The validity of the predicted ASM was evaluated by comparing it with the actual ASM measured using BIA. Moreover, we determined the ability of the predicted ASM and GS results to diagnose sarcopenia in patients with esophageal cancer before and 4 weeks after surgery.
A moderate agreement (before surgery: Lin concordance correlation coefficient [CCC] = 0.88; 4 weeks after surgery: Lin CCC = 0.89) was observed between the predicted ASM and the actual ASM. Furthermore, the predicted and measured ASM values showed substantial agreement in diagnosing sarcopenia (before surgery: κ statistics = 0.61; 4 weeks after surgery: κ statistic = 0.65).
The equation developed for predicting ASM in Japanese participants can be applied to patients with esophageal cancer.
双能X线吸收法和生物电阻抗分析（BIA）用于测量四肢骨骼肌质量（ASM）。然而，这两种方法在某些情况下可能不适用。因此，已经开发了使用人体测量参数来预测ASM的方程，这是一种成本较低且更可行的方法。本研究评估了使用先前报道的预测方程计算出的预测ASM与使用BIA测量的实际ASM之间的相关性。此外，我们确定了它们在诊断食管癌患者肌肉减少症方面的一致性程度。
从先前一项涉及119例食管癌患者的研究中，获取围手术期人体测量参数（身高、体重、腰围和臀围）以及握力（GS），使用先前报道的预测方程（Furushima方程）计算日本参与者的ASM。通过将预测的ASM与使用BIA测量的实际ASM进行比较来评估预测ASM的有效性。此外，我们确定了预测的ASM和GS结果在诊断食管癌患者术前和术后4周肌肉减少症方面的能力。
预测的ASM与实际的ASM之间观察到中等程度的一致性（术前：林氏一致性相关系数[CCC] = 0.88；术后4周：林氏CCC = 0.89）。此外，预测和测量的ASM值在诊断肌肉减少症方面显示出高度一致性（术前：κ统计量 = 0.61；术后4周：κ统计量 = 0.65）。
为预测日本参与者的ASM而开发的方程可应用于食管癌患者。
