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All genetic subtypes of B-cell acute lymphoblastic leukemia exhibit increased incidence rates in children with Down syndrome.

作者信息

Hsu Ching-Ju, Schraw Jeremy M, Desrosiers Tania A, Janitz Amanda E, Kirby Russell S, Nestoridi Eirini, Nembhard Wendy N, Salemi Jason L, Shumate Charles, Tanner Jean Paul, Yazdy Mahsa M, Scheurer Michael E, Rabin Karen R, Lupo Philip J

机构信息

Division of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.

Department of Epidemiology, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

出版信息

Leukemia. 2025 Apr 11. doi: 10.1038/s41375-025-02602-w.

DOI:10.1038/s41375-025-02602-w
PMID:40217070
Abstract
摘要

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All genetic subtypes of B-cell acute lymphoblastic leukemia exhibit increased incidence rates in children with Down syndrome.在唐氏综合征患儿中，B细胞急性淋巴细胞白血病的所有基因亚型发病率均有所增加。
Leukemia. 2025 Apr 11. doi: 10.1038/s41375-025-02602-w.
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Integrated genetic and epigenetic analysis revealed heterogeneity of acute lymphoblastic leukemia in Down syndrome.整合遗传和表观遗传分析揭示唐氏综合征急性淋巴细胞白血病的异质性。
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Deletions of the long arm of chromosome 5 define subgroups of T-cell acute lymphoblastic leukemia.5号染色体长臂缺失可定义T细胞急性淋巴细胞白血病的亚组。
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Development of acute lymphoblastic leukemia following treatment for acute myeloid leukemia in children with Down syndrome: A case report and retrospective review of Children's Oncology Group acute myeloid leukemia trials.唐氏综合征患儿急性髓系白血病治疗后继发急性淋巴细胞白血病：病例报告及儿童肿瘤协作组急性髓系白血病临床试验回顾性分析。
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引用本文的文献

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Vertebrate and Invertebrate Animal Models for the Study of Down Syndrome.用于唐氏综合征研究的脊椎动物和无脊椎动物模型。
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1
Children's Oncology Group blueprint for research: Acute lymphoblastic leukemia.儿童肿瘤学组研究蓝图：急性淋巴细胞白血病。
Pediatr Blood Cancer. 2023 Sep;70 Suppl 6(Suppl 6):e30585. doi: 10.1002/pbc.30585. Epub 2023 Jul 25.
2
Management of Down Syndrome-Associated Leukemias: A Review.唐氏综合征相关白血病的治疗：综述。
JAMA Oncol. 2023 Sep 1;9(9):1283-1290. doi: 10.1001/jamaoncol.2023.2163.
3
Associations between birth defects and childhood and adolescent germ cell tumors according to sex, histologic subtype, and site.
根据性别、组织学亚型和部位，出生缺陷与儿童和青少年生殖细胞肿瘤之间的关联。
Cancer. 2023 Oct 15;129(20):3300-3308. doi: 10.1002/cncr.34906. Epub 2023 Jun 27.
4
Genomic landscape of Down syndrome-associated acute lymphoblastic leukemia.唐氏综合征相关急性淋巴细胞白血病的基因组图谱。
Blood. 2023 Jul 13;142(2):172-184. doi: 10.1182/blood.2023019765.
5
Association Between Birth Defects and Cancer Risk Among Children and Adolescents in a Population-Based Assessment of 10 Million Live Births.基于1000万例活产的人群评估中儿童和青少年出生缺陷与癌症风险之间的关联
JAMA Oncol. 2019 Aug 1;5(8):1150-1158. doi: 10.1001/jamaoncol.2019.1215.
6
The prevalence of selected major birth defects in the United States.美国部分重大出生缺陷的流行情况。
Semin Perinatol. 2017 Oct;41(6):338-344. doi: 10.1053/j.semperi.2017.07.004.
7
Acute lymphoblastic leukemia in children with Down syndrome: a retrospective analysis from the Ponte di Legno study group.唐氏综合征儿童的急性淋巴细胞白血病：来自 Ponte di Legno 研究组的回顾性分析。
Blood. 2014 Jan 2;123(1):70-7. doi: 10.1182/blood-2013-06-509463. Epub 2013 Nov 12.
8
Down syndrome childhood acute lymphoblastic leukemia has a unique spectrum of sentinel cytogenetic lesions that influences treatment outcome: a report from the Children's Oncology Group.唐氏综合征儿童急性淋巴细胞白血病具有独特的标志性细胞遗传学病变谱，影响治疗结果：来自儿童肿瘤协作组的报告。
Blood. 2010 Aug 19;116(7):1045-50. doi: 10.1182/blood-2009-07-235291. Epub 2010 May 4.
9
Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group.唐氏综合征急性淋巴细胞白血病，一种高度异质性疾病，其中 CRLF2 的异常表达与突变型 JAK2 相关：来自国际 BFM 研究组的报告。
Blood. 2010 Feb 4;115(5):1006-17. doi: 10.1182/blood-2009-08-235408. Epub 2009 Nov 24.
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Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia.CRLF2在B祖细胞和唐氏综合征相关急性淋巴细胞白血病中的重排。
Nat Genet. 2009 Nov;41(11):1243-6. doi: 10.1038/ng.469. Epub 2009 Oct 18.