内侧颞叶癫痫中形态计量相似性网络的改变与神经炎症途径基因转录相关。
Alternations in morphometric similarity network in mesial temporal epilepsy correlate to neuroinflammatory pathway gene transcriptions.
作者信息
Lu Lu, Zhao Chenyang, Liao Weihao, Wang Peiyu, Zhang Yingying, An Dongmei, Wu Xintong, Zhang Hesheng, Jiang Ping, He Yaohui, Niu Jinpeng, Li Wei, Chen Kangjia, Lui Su, Zhao Yu, Gong Qiyong, Wang Bo, Liao Wei, Sander Josemir W, Chen Lin, Zhou Dong
机构信息
Department of Neurology, & Institute of Brain Science and Brain-Inspired Technology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Department of Radiology, West China Hospital, Sichuan University, Sichuan Province, Chengdu, 610041, China.
出版信息
Acta Epileptol. 2025 Mar 4;7(1):18. doi: 10.1186/s42494-025-00208-4.
BACKGROUND
Mesial temporal lobe epilepsy (mTLE) is the most common form of focal epilepsy, often associated with hippocampal sclerosis. Increasing evidence suggests the pivotal role of neuroinflammation in mTLE onset and progression.
METHODS
We used morphometric similarity network (MSN) analysis and the Allen Human Brain Atlas (AHBA) database to investigate structural changes between mTLE and healthy controls, as well as correlation with inflammation-related gene expression.
RESULTS
We identified widespread alterations across the frontal and parietal lobes and cingulate cortex linked to neuroinflammatory genes such as PRR5, SMAD3, and IRF3. This correlation was even more pronounced in mTLE patients with hippocampal sclerosis compared to those without. Enrichment analysis highlighted pathways related to neurodevelopment and neurodegeneration, supporting a bidirectional link between mTLE and neurodegenerative diseases.
CONCLUSIONS
These findings suggest that brain-wide macroscopic morphometric alternations in mTLE are correlated to the neuroinflammation process. It provides circumstantial evidence from a new perspective to support the bidirectional link between mTLE and neurodegenerative diseases.
背景
内侧颞叶癫痫（mTLE）是局灶性癫痫最常见的形式，常与海马硬化相关。越来越多的证据表明神经炎症在mTLE的发病和进展中起关键作用。
方法
我们使用形态计量相似性网络（MSN）分析和艾伦人类大脑图谱（AHBA）数据库来研究mTLE患者与健康对照之间的结构变化，以及与炎症相关基因表达的相关性。
结果
我们发现额叶、顶叶和扣带回皮质存在广泛的改变，这些改变与PRR5、SMAD3和IRF3等神经炎症基因相关。与没有海马硬化的mTLE患者相比，这种相关性在有海马硬化的mTLE患者中更为明显。富集分析突出了与神经发育和神经退行性变相关的通路，支持了mTLE与神经退行性疾病之间的双向联系。
结论
这些发现表明，mTLE患者全脑范围的宏观形态计量学改变与神经炎症过程相关。它从一个新的角度提供了间接证据，支持mTLE与神经退行性疾病之间的双向联系。
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