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肠道微生物制剂改善继发于获得性免疫缺陷综合征的癫痫：一例报告

Improvement of epilepsy secondary to acquired immunodeficiency syndrome with intestinal microbiota preparations: a case report.

作者信息

Lin Chuhui, Zeng Ting, Deng Yuhong

机构信息

Department of Clinical Nutrition, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.

Institute of Neuroscience and Department of Neurology, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.

出版信息

Acta Epileptol. 2024 Apr 15;6(1):12. doi: 10.1186/s42494-024-00156-5.

DOI:10.1186/s42494-024-00156-5
PMID:40217405
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11960214/
Abstract

BACKGROUND

Epilepsy secondary to acquired immunodeficiency syndrome (AIDS) can be challenging to manage. The potential interactions between antiretroviral drugs and antiepileptic drugs may result in the failure of both treatments. Therefore, it is crucial to develop more effective strategies to enhance the clinical outcomes of patients.

CASE PRESENTATION

We report a case of epilepsy secondary to AIDS. After administration of Bacteroides Fragilis 839 (BF839), the secondary generalized tonic-clonic seizures disappeared, the frequency of complex partial seizures decreased by 70%, and the duration of each episode was shortened. Additionally, long-term diarrhea associated with antiretroviral therapy for AIDS resolved, and the syphilis serofast reaction turned negative. No serious adverse reactions were observed during the three-year follow up.

CONCLUSIONS

This case report suggests that the specific gut microbiota preparation could possibly improve refractory epilepsy in HIV patients while also potentially alleviating adverse reactions to antiretroviral drugs and concurrent syphilis infection. Our case may provide a new perspective for the treatment of HIV infection/AIDS.

摘要

背景

获得性免疫缺陷综合征（AIDS）继发的癫痫可能难以管理。抗逆转录病毒药物和抗癫痫药物之间的潜在相互作用可能导致两种治疗均失败。因此，制定更有效的策略以提高患者的临床疗效至关重要。

病例报告

我们报告一例AIDS继发癫痫的病例。给予脆弱拟杆菌839（BF839）后，继发性全身强直阵挛发作消失，复杂部分性发作频率降低70%，且每次发作持续时间缩短。此外，与AIDS抗逆转录病毒治疗相关的长期腹泻得到缓解，梅毒血清固定反应转为阴性。在三年随访期间未观察到严重不良反应。

结论

本病例报告表明，特定的肠道微生物制剂可能改善HIV患者的难治性癫痫，同时还可能减轻对抗逆转录病毒药物的不良反应和并发的梅毒感染。我们的病例可能为HIV感染/AIDS的治疗提供新的视角。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/442b/11960214/fa9065cbaa96/42494_2024_156_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/442b/11960214/39e1308ed077/42494_2024_156_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/442b/11960214/6d75d42578ef/42494_2024_156_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/442b/11960214/fa9065cbaa96/42494_2024_156_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/442b/11960214/39e1308ed077/42494_2024_156_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/442b/11960214/6d75d42578ef/42494_2024_156_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/442b/11960214/fa9065cbaa96/42494_2024_156_Fig3_HTML.jpg

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