Qiu Chenxi, Zhong Chenxi, Liu Ying, Wang Liju, Tang Yingying, Liu Zhiyi, Guo Sijia, Jiang Yingqi, Li Enzhi, Lu Jing, Yan Bo, Hao Xiaoting, Zhou Dong
MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu , Sichuan, 611731, China.
Department of Neurology, West China Hospital, Sichuan University, Chengdu , Sichuan, 610041, China.
Acta Epileptol. 2024 Aug 25;6(1):26. doi: 10.1186/s42494-024-00170-7.
There is a lack of further exploration of the epileptogenic network of specific types of epilepsy, such as unilateral hippocampal sclerosis (HS), and there is an urgent need to find exact evidence to confirm the consistency of its brain network changes.
We enrolled 22 mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE-HS) patients to compare the differences in brain activity between 22 healthy controls (HCs) and them. Resting-state electroencephalography (EEG) was also measured. Then, we calculated the power spectral density and phase locking values in and between these electrodes.
The results showed the increased theta power was related to the high severity of epilepsy in the temporal, parietal, and central regions in mTLE-HS patients, and there were positive correlations between theta power in the contralateral temporal region and seizure frequency. Theta power in the ipsilateral parietal lobe is positively correlated with the number of anti-seizure medications (ASMs), but not with the usage of third-generation ASMs. Meanwhile, the temporal lobe of mTLE-HS patients had more connectivity with parietal lobe and central region.
Theta power is an important EEG indicator of mTLE-HS, positively correlates with epilepsy severity and seizure frequency, and has network properties that can be observed outside the lesion. Moreover, the usage of third-generation ASMs did not affect the risk of increased theta power. Lastly, the temporoparietal and temporal-central networks are likely to be causative pathways in epilepsy patients with cognitive impairment. This study provides a potential guideline for the treatment of mTLE-HS in clinical practice.
对于特定类型癫痫的致痫网络，如单侧海马硬化（HS），缺乏进一步探索，迫切需要找到确切证据来证实其脑网络变化的一致性。
我们招募了22例内侧颞叶癫痫伴海马硬化（mTLE-HS）患者，以比较22名健康对照者（HCs）与他们之间的脑活动差异。还测量了静息态脑电图（EEG）。然后，我们计算了这些电极内部和之间的功率谱密度和锁相值。
结果显示，θ功率增加与mTLE-HS患者颞叶、顶叶和中央区域癫痫的高严重程度相关，对侧颞叶区域的θ功率与癫痫发作频率之间存在正相关。同侧顶叶的θ功率与抗癫痫药物（ASM）的数量呈正相关，但与第三代ASM的使用无关。同时，mTLE-HS患者的颞叶与顶叶和中央区域有更多的连接。
θ功率是mTLE-HS的重要脑电图指标，与癫痫严重程度和发作频率呈正相关，并且具有可在病变外观察到的网络特性。此外，第三代ASM的使用并未影响θ功率增加的风险。最后，颞顶叶和颞中央网络可能是癫痫伴认知障碍患者的致病途径。本研究为临床实践中mTLE-HS的治疗提供了潜在指导。
