Livergant Iu M, Tarkhanova M V, Tkachenko G I, Petrenko V V
Med Radiol (Mosk). 1985 Jun;30(6):11-5.
A study was made of an effect of irradiation on pulmonary microcirculation using perfusion pulmoscintigraphy indicators. Altogether 13 breast cancer patients (9 with left-side and 4 with right-side involvement) and 9 thyroid cancer patients were examined before and after radiation therapy. Absorbed doses in breast cancer were determined by phantom measurements, for thyroid cancer by calculation. Perfusion pulmoscintigraphy with labeled albumin macroaggregate preceded and followed radiotherapy. Accumulation of the radioactivity of the drug in different pulmonary zones was taken into account. Slight changes of the microcirculation index found after irradiation, lead to a conclusion that in radiation therapy of breast cancer one can observe improvement of the blood flow in the pulmonary arterial system whereas in thyroid cancer a similar effect in the irradiated upper pulmonary zone was not marked. Irradiation of the root of the lung produces a more powerful effect on the pulmonary blood flow. Taking into account a sharp suppression of the arterial blood flow in some lung cancer patients (decreasing chemotherapy efficacy) it is suggested that change of the blood content developing after irradiation be used in the planning of combined therapy of lung cancer.
利用灌注肺闪烁显像指标对辐射对肺微循环的影响进行了一项研究。总共对13例乳腺癌患者（9例左侧受累，4例右侧受累）和9例甲状腺癌患者在放射治疗前后进行了检查。乳腺癌的吸收剂量通过体模测量确定，甲状腺癌的吸收剂量通过计算确定。在放疗前后进行了用标记白蛋白大颗粒的灌注肺闪烁显像。考虑了药物放射性在不同肺区的蓄积情况。照射后发现微循环指数有轻微变化，由此得出结论，在乳腺癌放射治疗中可观察到肺动脉系统血流改善，而在甲状腺癌中，照射的上肺区未观察到类似效果。肺根部照射对肺血流产生更强的影响。考虑到一些肺癌患者动脉血流的急剧抑制（降低化疗疗效），建议在肺癌联合治疗方案中利用照射后血液含量的变化。
