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产后抑郁症的流行病学、危险因素、诊断与管理:对当前知识及未来展望的评估

Postpartum Depression Epidemiology, Risk Factors, Diagnosis, and Management: An Appraisal of the Current Knowledge and Future Perspectives.

作者信息

Khamidullina Zaituna, Marat Aizada, Muratbekova Svetlana, Mustapayeva Nagima M, Chingayeva Gulnar N, Shepetov Abay M, Ibatova Syrdankyz S, Terzic Milan, Aimagambetova Gulzhanat

机构信息

Department of Obstetrics and Gynecology #1, NJSC "Astana Medical University", Astana 010000, Kazakhstan.

Higher School of Medicine, NJSC Sh. Ualikhanov Kokshetau University, Kokshetau 020000, Kazakhstan.

出版信息

J Clin Med. 2025 Apr 1;14(7):2418. doi: 10.3390/jcm14072418.

DOI:10.3390/jcm14072418
PMID:40217868
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11989329/
Abstract

Postpartum depression (PPD) is a severe mental health condition that affects women following childbirth and is marked by persistent sadness, anxiety, fatigue, and difficulty functioning. Unlike the temporary "baby blues", PPD is more severe and long-lasting, potentially leading to negative consequences for mother and child. Globally, PPD impacts approximately 10-20% of postpartum women, with prevalence influenced by genetic, hormonal, psychological, and socio-environmental factors. Early detection is crucial, with screening tools such as the Edinburgh Postnatal Depression Scale (EPDS) commonly used in clinical practice. Treatment options include pharmacological interventions such as selective serotonin reuptake inhibitors (SSRIs), psychological therapies like cognitive behavioral therapy (CBT) and interpersonal therapy (IPT), and lifestyle modifications. Despite the growing awareness of PPD, stigma remains a significant barrier to treatment, discouraging many women from seeking help. In low-income countries, where mental health care is often underfunded, accessing professionals trained in perinatal mental health presents an even greater challenge. This gap underscores the urgent need for a collaborative, multidisciplinary approach involving obstetricians, psychiatrists, pediatricians, and midwives to ensure comprehensive support and care for affected individuals.

摘要

产后抑郁症(PPD)是一种严重的心理健康状况,影响产后女性,其特征为持续的悲伤、焦虑、疲劳以及功能障碍。与短暂的“产后情绪低落”不同,产后抑郁症更为严重且持续时间更长,可能对母亲和孩子产生负面后果。在全球范围内,产后抑郁症影响着约10%-20%的产后女性,其患病率受遗传、激素、心理和社会环境因素影响。早期检测至关重要,临床实践中常用爱丁堡产后抑郁量表(EPDS)等筛查工具。治疗选择包括药物干预,如选择性5-羟色胺再摄取抑制剂(SSRIs),心理治疗,如认知行为疗法(CBT)和人际治疗(IPT),以及生活方式的改变。尽管对产后抑郁症的认识不断提高,但耻辱感仍然是治疗的重大障碍,阻碍许多女性寻求帮助。在低收入国家,心理健康护理往往资金不足,获得围产期心理健康方面受过培训的专业人员面临更大挑战。这一差距凸显了迫切需要一种由产科医生、精神科医生、儿科医生和助产士参与的协作性多学科方法,以确保为受影响的个体提供全面支持和护理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4986/11989329/6b022cd4a902/jcm-14-02418-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4986/11989329/90e4a25646b2/jcm-14-02418-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4986/11989329/aec16cbe51b8/jcm-14-02418-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4986/11989329/6b022cd4a902/jcm-14-02418-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4986/11989329/90e4a25646b2/jcm-14-02418-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4986/11989329/aec16cbe51b8/jcm-14-02418-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4986/11989329/6b022cd4a902/jcm-14-02418-g003.jpg

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本文引用的文献

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JMA J. 2024 Oct 15;7(4):600-602. doi: 10.31662/jmaj.2024-0070. Epub 2024 Aug 9.
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Maternal postpartum health and its impact on health and development of young children.产妇产后健康及其对幼儿健康与发育的影响。
Womens Health Nurs. 2024 Jun;30(2):96-100. doi: 10.4069/whn.2024.03.30. Epub 2024 May 24.
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Screening Recommendations and Treatments for Postpartum Depression-Reply.产后抑郁症的筛查建议与治疗——回复
JAMA. 2024 Apr 2;331(13):1154. doi: 10.1001/jama.2024.1634.
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Diagnosis of peripartum depression disorder: A state-of-the-art approach from the COST Action Riseup-PPD.围产期抑郁障碍的诊断:COST 行动 Riseup-PPD 的最新方法。
Compr Psychiatry. 2024 Apr;130:152456. doi: 10.1016/j.comppsych.2024.152456. Epub 2024 Jan 29.
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Childbirth-related posttraumatic stress disorder: definition, risk factors, pathophysiology, diagnosis, prevention, and treatment.分娩相关创伤后应激障碍:定义、风险因素、病理生理学、诊断、预防和治疗。
Am J Obstet Gynecol. 2024 Mar;230(3S):S1116-S1127. doi: 10.1016/j.ajog.2023.09.089. Epub 2024 Jan 9.
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Non-Obstetric Maternal Mortality Trends by Race in the United States.美国按种族划分的非产科产妇死亡率趋势。
Matern Child Health J. 2024 May;28(5):895-904. doi: 10.1007/s10995-023-03862-7. Epub 2023 Dec 26.
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Baby blues, premenstrual syndrome and postpartum affective disorders: intersection of risk factors and reciprocal influences.产后情绪低落、经前综合征与产后情感障碍:风险因素的交叉及相互影响
BJPsych Open. 2023 Dec 4;10(1):e3. doi: 10.1192/bjo.2023.612.
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Curr Psychiatry Rep. 2023 Dec;25(12):803-808. doi: 10.1007/s11920-023-01471-3. Epub 2023 Oct 31.
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