Adeniran Esther A, Quinn Megan, Liu Ying, Brooks Billy, Pack Robert P
Cedars-Sinai Cancer, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Department of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, TN 37614, USA.
Healthcare (Basel). 2025 Apr 2;13(7):798. doi: 10.3390/healthcare13070798.
An effective treatment for Opioid Use Disorder is Medication-Assisted Treatment (MAT). However, in the United States (US), this is still being underutilized by youth. Research indicates the need to develop strategies to reduce treatment barriers among these youth. Thus, we explored the rates of treatment completion and dropout among youth receiving MAT in US substance use treatment facilities and examined factors associated with treatment completion and dropout.
This study used the 2019 Treatment Episode Data Set-Discharges. Our analysis was restricted to youth (12-24 years) who primarily used heroin at admission. Log-binomial regression was used to examine various determinants of treatment completion and dropout, guided by Andersen's Behavioral Model.
The final sample size was 4917. Among youth reporting heroin use with receipt of MAT, those showing a higher likelihood of treatment completion than dropout were males [ARR: 1.23; 95% CI: 1.088-1.381; = 0.0008], had 1-7 times [ARR: 1.33; 95% CI: 1.115-1.584; = 0.0015] and 8-30 times self-help group participation [ARR: 1.50; 95% CI: 1.246-1.803; < 0.0001], had co-occurring mental and substance use disorders [ARR: 1.28; 95% CI: 1.133-1.448, < 0.0001], were admitted to detoxification [ARR: 2.80; 95% CI: 2.408-3.255; < 0.0001] and residential/rehabilitation settings [ARR: 2.05; 95% CI: 1.749-2.400; < 0.0001], and were located in the Midwest/West [ARR: 1.18; 95% CI: 1.030-1.358; = 0.0173]. Conversely, other races (excluding Whites and Blacks/African Americans) [ARR: 0.75; 95% CI: 0.609-0.916; = 0.0051], those who used MAT [ARR: 0.81; 95% CI: 0.694-0.946; = 0.0077], and youth in the South [ARR: 0.45; 95% CI: 0.369-0.549; < 0.0001] were less likely to report treatment completion than dropout.
The majority of youth receiving MAT dropped out of treatment. We identified various factors that should be prioritized to address youth underutilization of MAT in the US.
药物辅助治疗(MAT)是治疗阿片类物质使用障碍的一种有效方法。然而,在美国,青少年对这种治疗方法的使用率仍然很低。研究表明,有必要制定策略来减少这些青少年的治疗障碍。因此,我们探讨了在美国物质使用治疗机构接受MAT治疗的青少年的治疗完成率和辍学率,并研究了与治疗完成和辍学相关的因素。
本研究使用了2019年治疗事件数据集-出院数据。我们的分析仅限于入院时主要使用海洛因的青少年(12 - 24岁)。在安德森行为模型的指导下,使用对数二项回归来研究治疗完成和辍学的各种决定因素。
最终样本量为4917。在报告使用海洛因并接受MAT治疗的青少年中,治疗完成可能性高于辍学可能性的有男性[风险比(ARR):1.23;95%置信区间(CI):1.088 - 1.381;P = 0.0008],自助小组参与次数为1 - 7次[ARR:1.33;95% CI:1.115 - 1.584;P = 0.0015]和8 - 30次[ARR:1.50;95% CI:1.246 - 1.803;P < 0.0001],同时患有精神和物质使用障碍[ARR:1.28;95% CI:1.133 - 1.448;P < 0.0001],被收治到戒毒所[ARR:2.80;95% CI:2.408 - 3.255;P < 0.0001]和住院/康复机构[ARR:2.05;95% CI:1.749 - 2.400;P < 0.0001],以及位于中西部/西部地区[ARR:1.18;95% CI:1.030 - 1.358;P = 0.0173]。相反,其他种族(不包括白人和黑人/非裔美国人)[ARR:0.75;95% CI:0.609 - 0.916;P = 0.0051]、使用MAT的人[ARR:0.81;95% CI:0.694 - 0.946;P = 0.0077]以及南部地区的青少年[ARR:0.45;95% CI:0.369 - 0.549;P < 0.0001]报告治疗完成的可能性低于辍学可能性。
大多数接受MAT治疗的青少年中途退出了治疗。我们确定了在美国应对青少年对MAT利用不足问题时应优先考虑的各种因素。