Seferoğlu Meral, Tunç Abdulkadir, Sıvacı Ali Özhan, Öncel Samed, Düztaban Tuğba, Dikilitaş Hamide, Görgül Abdul Samed, Öztürkci Muhammed Furkan
Department of Neurology, University of Health Sciences, Bursa Yüksek Ihtisas Training and Research Hospital, Bursa 16310, Turkey.
Department of Neurology, Faculty of Medicine, Sakarya University, Sakarya 54100, Turkey.
Diagnostics (Basel). 2025 Apr 6;15(7):936. doi: 10.3390/diagnostics15070936.
Mobility impairments in multiple sclerosis (MS) significantly affect quality of life. This study evaluated the clinical utility and sensitivity of the Backward Timed 25-Foot Walk Test (B-T25FW) and its associations with key clinical measures in MS. : A cross-sectional study was conducted with 129 ambulatory patients with MS from two centers. Disability (Expanded Disability Status Scale, EDSS), cognition (Symbol Digit Modalities Test, SDMT), manual dexterity (Nine-Hole Peg Test, 9HPT), fatigue, and forward and backward walking were assessed. Correlation and receiver operating characteristic (ROC) analyses were performed. : The participants included in the study were 76% female, with a mean age of 38 years, and the majority were diagnosed with relapsing-remitting MS (86.8%). Backward and forward walking times significantly correlated with key clinical measures, including the EDSS, SDMT, and 9HPT. Backward walking times showed moderate correlations with EDSS (r = 0.469) and weaker but significant correlations with 9HPT (r = 0.452) and disease duration (r = 0.245). Both walking tests were negatively correlated with SDMT scores. For prognostic purposes, forward walking exhibited slightly higher predictive power compared to backward walking. : The B-T25FW is a clinically relevant, practical, and sensitive tool for assessing mobility impairments in individuals with MS. Its integration into clinical practice could complement forward walking assessments, enhancing disease monitoring and guiding interventions. Future research should validate its longitudinal utility.
多发性硬化症（MS）中的运动障碍会显著影响生活质量。本研究评估了反向计时25英尺步行测试（B-T25FW）的临床实用性和敏感性及其与MS关键临床指标的关联。：对来自两个中心的129例非卧床MS患者进行了一项横断面研究。评估了残疾程度（扩展残疾状态量表，EDSS）、认知能力（符号数字模态测试，SDMT）、手部灵活性（九孔插板测试，9HPT）、疲劳以及向前和向后行走情况。进行了相关性分析和受试者操作特征（ROC）分析。：纳入研究的参与者中76%为女性，平均年龄38岁，大多数被诊断为复发缓解型MS（86.8%）。向后和向前行走时间与包括EDSS、SDMT和9HPT在内的关键临床指标显著相关。向后行走时间与EDSS呈中度相关（r = 0.469），与9HPT呈较弱但显著的相关（r = 0.452），与病程呈显著相关（r = 0.245）。两项步行测试均与SDMT得分呈负相关。为了进行预后评估，向前行走相比向后行走表现出略高的预测能力。：B-T25FW是一种用于评估MS患者运动障碍的临床相关、实用且敏感的工具。将其纳入临床实践可以补充向前行走评估，加强疾病监测并指导干预措施。未来的研究应验证其纵向效用。
