Zhao Mingxia, Qiao Kaina, Zhang Lili, Liang Li, Chen Shuxing, Chen Lishui, Zhang Yuyu
Food Laboratory of Zhongyuan·Beijing Technology and Business University, Luohe 462300, China.
Food Laboratory of Zhongyuan, Luohe Food Engineering Vocational University, Luohe 462000, China.
Nutrients. 2025 Mar 28;17(7):1181. doi: 10.3390/nu17071181.
Hyperlipidemia is a metabolic disorder in which cholesterol (TC) and triglycerides (TGs) in the blood exceed the normal physiological levels. The incidence of the condition has continued to rise in recent years, posing a serious threat to public health. Its clinical treatment mainly relies on drug interventions, such as statins, fibrate, and niacin. Although these drugs have shown some efficacy in the treatment of hyperlipidemia, their adverse effects cannot be ignored. In contrast, naturally derived peptides have gradually become potential candidates for the prevention and treatment of hyperlipidemia due to their strong anti-hyperlipidemic activity and safety; examples of such peptides include those from dairy products, grains, legumes, and seafood. This review systematically summarizes peptides with anti-hyperlipidemic activity and analyzes their mechanisms of action, providing a theoretical basis for further research. In addition, we also outline some challenges facing the application of peptides, hoping to prevent hyperlipidemia and reduce its incidence by encouraging the consumption of foods rich in anti-hyperlipidemia peptides.
高脂血症是一种代谢紊乱疾病，其中血液中的胆固醇（TC）和甘油三酯（TGs）超过正常生理水平。近年来，该疾病的发病率持续上升，对公众健康构成严重威胁。其临床治疗主要依赖药物干预，如他汀类药物、贝特类药物和烟酸。尽管这些药物在治疗高脂血症方面已显示出一定疗效，但其不良反应不容忽视。相比之下，天然来源的肽由于其强大的抗高脂血症活性和安全性，已逐渐成为预防和治疗高脂血症的潜在候选物；此类肽的例子包括来自乳制品、谷物、豆类和海鲜的肽。本综述系统地总结了具有抗高脂血症活性的肽，并分析了它们的作用机制，为进一步研究提供理论依据。此外，我们还概述了肽应用面临的一些挑战，希望通过鼓励食用富含抗高脂血症肽的食物来预防高脂血症并降低其发病率。
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