Wang Yingying, Deng Chengdan, Li Hailong, Gao Yingxue, Shi Bing, Huang Xiaoqi, Gong Qiyong
Department of Radiology, Huaxi MR Research Center (HMRRC), Institution of Radiology and Medical Imaging, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Functional and Molecular lmaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Eur J Neurosci. 2025 Apr;61(7):e70077. doi: 10.1111/ejn.70077.
Cleft lip and palate (CLP) may induce alterations in functional connectivity (FC) throughout the whole brain, potentially leading to speech dysfunctions; however, the precise neurobiological mechanisms involved remain unknown. This study aimed to systematically examine the consequences of neurological impairments associated with CLP on whole-brain FC and speech functionality. A total of 33 CLP individuals and 41 control participants were included in this study. Eight meaningful brain networks were identified through independent component analysis (ICA). The intergroup differences and correlations with speech scores for both intranetwork and internetwork FC were calculated. We observed decreased FC within the sensorimotor network (SMN), default mode network (DMN), and cerebellar network (CN) and increased FC within the executive control network (ECN). Additionally, FC was enhanced between the SMN and the auditory network (AN), attention network (ATN), and salience network (SAN); between the DMN and the visual network (VN) and ECN; and between two independent components of the DMN. Furthermore, significant correlations were observed between altered FC and speech assessment scores. Our research demonstrated that brain plasticity in CLP individuals with speech deficits involves widespread changes in brain connectivity, significantly improving our understanding of the neural basis of speech impairment in CLP individuals.
唇腭裂（CLP）可能会导致全脑功能连接（FC）的改变，进而可能导致言语功能障碍；然而，其中确切的神经生物学机制仍不清楚。本研究旨在系统地研究与CLP相关的神经损伤对全脑FC和言语功能的影响。本研究共纳入了33名CLP个体和41名对照参与者。通过独立成分分析（ICA）确定了八个有意义的脑网络。计算了组间差异以及网络内和网络间FC与言语分数的相关性。我们观察到感觉运动网络（SMN）、默认模式网络（DMN）和小脑网络（CN）内的FC降低，而执行控制网络（ECN）内的FC增加。此外，SMN与听觉网络（AN）、注意力网络（ATN）和突显网络（SAN）之间；DMN与视觉网络（VN）和ECN之间；以及DMN的两个独立成分之间的FC增强。此外，在FC改变与言语评估分数之间观察到显著相关性。我们的研究表明，有言语缺陷的CLP个体的大脑可塑性涉及大脑连接的广泛变化，显著增进了我们对CLP个体言语障碍神经基础的理解。
