催乳素和糖皮质激素对糖尿病及泌乳大鼠肝脏和乳腺中磷酸烯醇丙酮酸羧激酶活性的影响。
Effect of prolactin and glucocorticoids on P-enolpyruvate carboxykinase activity in liver and mammary gland from diabetic and lactating rats.
作者信息
Lobato M F, Careche M, Ros M, Moreno F J, García-Ruíz J P
出版信息
Mol Cell Biochem. 1985 May;67(1):19-23. doi: 10.1007/BF00220981.
The administration of 2 bromo-alpha-ergocryptine, to reduce serum prolactin decreased the activity of cytosolic P-enolpyruvate carboxykinase (GTP) (EC 4.1.1.32) about 50% in both liver and mammary gland of lactating animals. Adrenalectomy had similar effects to those of bromo-alpha-ergocryptine. In contrast, there was a 50% increase in enzyme activity in the mammary gland of diabetic, lactating rats and a 10-fold increase in liver as compared with normal rats. P-enolpyruvate carboxykinase activity in mammary gland as liver is coordinately regulated by prolactin, glucocorticoids and insulin.
给予2-溴-α-麦角隐亭以降低血清催乳素水平，可使泌乳动物肝脏和乳腺中胞质磷酸烯醇式丙酮酸羧激酶（GTP）（EC 4.1.1.32）的活性降低约50%。肾上腺切除术产生的效果与溴-α-麦角隐亭相似。相比之下，糖尿病泌乳大鼠乳腺中的酶活性比正常大鼠增加了50%，肝脏中的酶活性增加了10倍。乳腺和肝脏中的磷酸烯醇式丙酮酸羧激酶活性受催乳素、糖皮质激素和胰岛素的协同调节。
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